The role of synphilin-1 in the pathogenesis of Parkinson’s disease  

作　　者：Rui ZHENG Hai-Yan ZHOU Sheng-Di CHEN 

机构地区：[1]Department of Neurology and Institute of Neurology, Shanghai Jiaotong University School of Medicine, Shanghai 200025,China

出　　处：《Neuroscience Bulletin》2006年第4期239-243,共5页神经科学通报（英文版）

摘　　要：Parkinson’s disease (PD) is one of the commonest neurodegenerative disorders characterized by the loss of dopaminergic (DAergic) neurons in the substantia nigra and the appearance of Lewy bodies (LBs), whose cytoplasmic inclusions are highly enriched with ubiquitin, synphilin-1, α-synuclein and parkin. Synphilin-1 is an α-synuclein-binding protein and a major component of LBs. It is widely accepted that synphilin-1 is involved in the pathogenic process of PD. This review will provide an overall view of the role of synphilin-1 in the pathogenesis of Parkinson’s disease and the latest findings in this field.Parkinson＇s disease （PD） is one of the commonest neurodegenerative disorders characterized by the loss of dopaminergic （DAergic） neurons in the substantia nigra and the appearance of Lewy bodies （LBs）, whose cytoplasmic inclusions are highly enriched with ubiquitin, synphilin- 1, α-synuclein and park：in. Synphilin- 1 is an α-synuclein-binding protein and a major component of LBs, It is widely accepted that synphilin- 1 is involved in the pathogenic process of PD. This review will provide an overall view of the role of synphilin- 1 in the pathogenesis of Parkinson＇ s disease and the latest findings in this field.

关 键 词：synphlin- 1 Parkinson＇s disease Α-SYNUCLEIN 

分 类 号：R742.5[医药卫生—神经病学与精神病学]