嘧啶核苷类似物的合成及其抗病毒活性  

SYNTHESIS AND ANTIVIRAL ACTIVITY OF ANALOGS OF PYRIMIDINE NUCLEOSIDE

作　　者：钟蒙[1] 赵莉[1] 文晓霞[1] 徐丽君[1] 李明霞[1] 吴美青 

机构地区：[1]山东医科大学药学系

出　　处：《中国医药工业杂志》1996年第8期344-346,共3页Chinese Journal of Pharmaceuticals

摘　　要：设计合成了５个尿嘧啶－１－乙醛缩（Ｎ４－取代氨基硫脲）衍生物并对其进行了抗家蚕核型多角体病毒及家蚕细胞质型多角体病毒活性实验。结果表明，这５个化合物具有不同程度的抑制作用。Five uracil-1-acetaldehyde (N￣4 -substituted thiosemicarbazones were synthesized by condensation of N￣4-substituted thiosemicarbazides with uracil-1-acetaldehyde.Antiviral activity against Nuclear Polyhedrosis Virus(NPV) and Cytoplasic Polyhedrosis Virus (CPV) in silkworms were tested in vivo.The results showed that all compounds possessed significant activity against NPV and two of them exhibited high activity against CPV.

关 键 词：尿嘧啶衍生物 缩氨基硫脲 

分 类 号：TQ463.54[化学工程—制药化工]