大肠癌与溃疡性结肠炎患者血清微量元素测定  

Determination of Trace Element Contents in the Serumof Patients with Carcinoma of Large Intestineand Ulcerative Colitis

作　　者：田虹[1] 王俊雅[1] 尹颂超[1] 缪惠标[1] 梁业成[1] 李增禧 

机构地区：[1]中山医科大学附属第三医院,广东省测试分析研究所

出　　处：《广东微量元素科学》1996年第9期24-26,共3页Trace Elements Science

摘　　要：用ＩＣＰ－ＡＥＳ方法，对３０例大肠癌、２６例溃疡性结肠炎进行血清钼、锌、铬、铁、铜、锰、铅、铝、硒、铋、钡、钛、钴、钒等微量元素测定，并与２０例健康者对照。结果显示大肠癌组血清钼（±ＳＤ＝０．２１±０．１０μｍｏｌ／Ｌ）、锌（±ＳＤ＝１．６５±１．３４μｍｏｌ／Ｌ）、铬（±ＳＤ＝１．６５±１．３４μｍｏｌ／Ｌ）低于对照组钼（±ＳＤ＝１．１９±０．３１μｍｏｌ／Ｌ）、锌（±ＳＤ＝２０．９４±６．３１μｍｏｌ／Ｌ）、铬（±ＳＤ＝２．８８±１．１５μｍｏｌ／Ｌ），Ｐ分别＜０．０１、＜０．０５、＜０．０５；溃疡性结肠炎组钼（±ＳＤ＝０．２１±０．０８μｍｏｌ／Ｌ）低于对照组，Ｐ＜０．０５。提示微量元素代谢异常可能直接影响酶系统，使自由基失控，体内促氧化和抗氧化平衡失调，促使肿瘤的发生。钼、锌、铬在大肠癌的发病中起一定作用。Contents of trace elements(Mo,Zn,Cu,Fe,Ba,Se,Mn,Sr,Ti,Ni,Bi)in theserum of 30 carcinoma of large intestine patients, 26 ulcerative colitis patients were determined by ICP-AES and compared with 20 cases of normal persons. The results show that thepatients with carcinoma of large intestine have contents of Mo 0.21±0.10,Zn 14.94±7.7,Cr 1.65±1.34 μmol/L,the patients with ulcerative colitis have Mo 0. 208±0. 08 μmol/L,normal controls have Mo 1.19± 0.31,Zn 20.94±6.31,Cr 2.88±1.15 μmol/L.The contentsof Mo,Zn,Cr for patients with carcinoma of large intestine are remarkably lower than for thenormal controls,P<0.01 or P<0.05.Content of Mo for patients with ulcerative colitis isremarkably lower than for the normal controls,P<0.01.This suggests that the abnormalmetabolism of trace elements in patients with carcinoma of large intestine and ulcerative directly affects the enzyme system, causing the free radical to get out of control and imbalanceof oxidation metabolism. This mechanism will probably be referred to the occurrence of carcinoma.

关 键 词：微量元素 大肠癌 溃疡性结肠炎 血清 测定 

分 类 号：R735.34[医药卫生—肿瘤] R574.62[医药卫生—临床医学]