动物受精过程中卵子Ca^(2+)释放机制  

Ca^(2+) RELEASE MECHANISMS OF OOCYTE AT FERTILIZATION

作　　者：郑克刚[1] 孟小倩[1] 李云龙[1] 

机构地区：[1]山东师范大学生命科学学院动物抗性省重点实验室,济南250014

出　　处：《山东师范大学学报（自然科学版）》2006年第3期120-122,共3页Journal of Shandong Normal University(Natural Science)

摘　　要：Ca2+是动物受精过程中卵内重要的第二信使,它对于皮质颗粒的排放、减数分裂的恢复、原核形成等过程具有重要的作用,受精过程中Ca2+的释放机制研究是当今受精生物学研究的热点之一,已有的研究结果表明动物卵子在受精过程中有三种Ca2+释放机制:由1,4,5,三磷酸肌醇引发内质网中储存的Ca2+释放、由环腺苷酸二核苷酸磷核糖引发与其相关联的钙库Ca2+释放和烟酸腺嘌呤二核苷酸磷酸引发的与其相关联的钙库Ca2+释放.Eggs from different animal species were studied to date elicit single or repetitive Ca^2＋ transients in response to fertilizing sperm. As an important second messenger, Ca^2＋ triggers a broad range of cellular reactions, including cortical granule release, completion of meiosis and pronuclear formation in oocyte. There are three mechanisms for Ca^2＋ release： inositol 1,4, 5 - trisphosphate pathway, cyclic ADP - fibose pathway and nicotinic acid adenine dinucleotide phosphate pathway.

关 键 词：受精 CA^2+ IP3 CADPR NAADP 

分 类 号：Q492.5[生物学—生理学]