云南高校图书馆联盟文献共享服务平台- CADPR

CADPR: 作品数：17被引量：20H指数：2; 导出分析报告; 相关领域：生物学更多>>; 相关作者：张礼和张亮仁杨振军崇蕾陈秀珍更多>>; 相关机构：北京大学温州医科大学复旦大学中国科学院更多>>; 相关期刊：《Science China(Life Sciences)》《质谱学报》《Acta Pharmacologica Sinica》《山东师范大学学报（自然科学版）》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划北京市教育委员会科技发展计划更多>>

抑制脊髓NMDAR⁃cADPR⁃RyRs信号通路减弱瑞芬太尼诱发的大鼠术后痛觉过敏被引量：1: 《基础医学与临床》2023年第9期1335-1340,共6页钱玥王芳张兢夏天娇顾小萍; 国家自然科学基金(81701371,81730033);江苏省自然科学基金(BK20170654)。; 目的探讨NMDAR-cADPR-RyRs信号通路在瑞芬太尼诱发的大鼠痛觉过敏中的作用。方法建立瑞芬太尼诱发(术后)痛觉过敏(RIH)大鼠模型。将大鼠按随机数字表法分为6组(n=8):对照组、手术组、痛觉过敏(RIH)组、0.9%氯化钠溶液组、氯胺酮组和环...; 关键词：瑞芬太尼痛觉过敏氯胺酮 8-溴-环二磷酸腺苷核糖兰尼碱受体

右美托咪定基于CD38/cADPR通路对罗哌卡因致惊厥大鼠大脑氧化应激的保护作用被引量：6: 《疑难病杂志》2021年第8期826-830,共5页朱荣誉向俊李传进朱贤林吴述轩; 国家自然科学基金项目(81760257)。; 目的观察右美托咪定是否经CD38/cADPR通路发挥抑制罗哌卡因致惊厥大鼠大脑氧化应激的作用。方法2020年1月—2021年1月于湖北省恩施土家族苗族自治州中心医院进行实验,选择SPF级雄性大鼠60只,随机数字表法选取20只作为空白对照组,其余40...; 关键词：惊厥右美托咪定 CD38/cADPR通路罗哌卡因氧化应激大鼠

Omega-3 fatty acids induce Ca2＋ mobilization responses in human colon epithelial cell lines endogenously expressing FFA4: 《Acta Pharmacologica Sinica》2015年第7期813-820,共8页Jung-min KIM Kyoung-pil LEE Soo-jin PARK Saeromi KANG Jin HUANG Jung-min LEE Koichi SATO Hae-young CHUNG Fumikazu OKAJIMA Dong-soon IM; Aim： Free fatty acid receptor 4 （FFA4; formerly known as GPR120） is the G protein-coupled receptor （GPCR） for omega-3 poly- unsaturated fatty acids. FFA4 has been found to express in the small intestines and colo...; 关键词：long-chain fatty acid omega-3 a-linolenic acid FFA4 Ca2＋ mobilization CADPR human colon epithelial cells

A novel method for the synthesis of sulfur substituted-cyclopyrophosphate of cADPR analogs: 《Chinese Chemical Letters》2014年第12期1583-1585,共3页Ren-Min Wu Na Qi Yu-Wen Jia Zhu Guan Liang-Ren Zhang Li-He Zhang Zhen-Jun Yang; scientific research funding from the National Natural Science Foundation of China(Nos.21332010,21172010, 21002004); A facile and efficient protocol for the synthesis of sulfur substituted-cyclopyrophosphate of cIDPRE（P_S^1-cIDPRE） was developed.The key step was the cyclization process which was completed by the sulfur substituted...; 关键词：cADPR cIDPRE Phosphoramidite strategy Cyclopyrophosphate

WJSC 6^(th) Anniversary Special Issues(2):Mesenchymal stem cells Purinergic receptors and nucleotide processing ectoenzymes:Their roles in regulating mesenchymal stem cell functions被引量：1: 《World Journal of Stem Cells》2014年第2期153-162,共10页Sonia Scarfì; Human mesenchymal stem cells(MSCs)are a rare population of non-hematopoietic stem cells with multilineage potential,originally identified in the bone marrow.Due to the lack of a single specific marker,MSCs can be reco...; 关键词：MESENCHYMAL stem cell PURINERGIC receptors Ectoenzymes ATP β-NAD ADENOSINE CADPR

Roles of cADPR and NAADP in pancreatic cells: 《Acta Biochimica et Biophysica Sinica》2012年第9期719-729,共11页Yongjuan Zhao Richard Graeff Hon Cheung Lee; This work was supported by the grants from the Council of Hong Kong （Nos. 769107, 768408, 769309 and 770610） and the National Natural Science Foundation of China/the Research Grants Council ofHong Kong （No. N_HKU 722/08）.; Cyclic ADP-ribose （cADPR） and nicotinic acid adenine dinucleotide phosphate （NAADP） are Ca2＋-mobilizing nucleotides that were discovered in the late 1980s. Two decades of investigations have built up a considerab...; 关键词：CADPR NAADP ADP-ribosyl cyclase Ca2＋ signaling Ca2＋ store pancreatic acinar cell

Design and synthesis of cADPR analogues with simplified ribose and nucleobase: 《Journal of Chinese Pharmaceutical Sciences》2012年第4期287-291,共5页周玥余沛霖杨振军张亮仁张礼和; National Natural Sciences Foundation of China (Grant No. 90713005,20910094);the Ministry of Education of China (Grant No. 200800010078); New cADPR mimic 5 that integrates the simplified nucleobase and ribose was designed and synthesized by using Cu（I）-catalyzed Huisgen [3＋2] cycloaddition to build the simplified triazole nucleobase and microwave-ass...; 关键词：CADPR Click chemistry Microwave-assistance Synthesis

Cyclic ADP-ribose and NAADP:fraternal twin messengers for calcium signaling被引量：9: 《Science China(Life Sciences)》2011年第8期699-711,共13页Hon Cheung LEE; supported by the Research Grants Council of Hong Kong(Grant Nos.769107,768408, 769309 and 770610);the National Natural Science Foundation of China/the Research Grants Council of Hong Kong(Grant No.N_HKU 722/08); The concept advanced by Berridge and colleagues that intracellular Ca2+-stores can be mobilized in an agonist-dependent and messenger(IP3)-mediated manner has put Ca 2+-mobilization at the center stage of signal trans...; 关键词：cyclic ADP-ribose CADPR NAADP nicotinic acid adenine dinucleotide phosphate CD38 ADP-ribosyl cyclase Calcium mobilization and signaling

Optimization of microwave-assisted synthesis of N^1-ethoxymethyl-substituted cyclic inosine diphosphoribose and its analogues: 《Journal of Chinese Pharmaceutical Sciences》2011年第6期557-563,共7页刘剑杨振军张亮仁张礼和; National Natural Science Foundation of China (Grant No.20910094) ;Ministry of Education of China(Grant No.200800010078); An optimized approach for the synthesis of N^1-ethoxymethyl-substituted cyclic inosine diphosphoribose（cIDPRE）,an analogue of cyclic adenosine diphosphoribose（cADPR）,has been developed via microwave-assisted intra...; 关键词：CADPR cIDPRE Chemical synthesis Microwave-assisted synthesis

cADPR解离过程的拉伸分子动力学模拟: 《中国药物化学杂志》2011年第2期114-119,共6页司原琦金宏威刘振明张亮仁张礼和; 国家自然科学基金项目(20910094;90713005); 目的研究cADPR从CD38活性口袋解离的过程中配体和受体间的相互作用,并寻找接近真实条件的蛋白结构模型。方法采用拉伸分子动力学的方法模拟cADPR从CD38活性口袋解离的过程。在cGDPR和CD38晶体复合物基础上进行修改,得到cADPR和CD38的复...; 关键词：CD38 CADPR ADP-核糖环化酶拉伸分子动力学

CADPR