PURINERGIC

作品数：40被引量：40H指数：4
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相关领域：医药卫生生物学更多>>
相关作者：任雷鸣刘坤丁旭东赵广翊郑宁宁更多>>
相关机构：河北医科大学中国医科大学浙江大学中国科学院上海生命科学研究院更多>>
相关期刊：《World Journal of Dermatology》《Acta Pharmacologica Sinica》《World Journal of Hematology》《Pharmacology & Pharmacy》更多>>
相关基金：国家自然科学基金沈阳市科技计划项目贝朗麻醉科学研究基金中国博士后科学基金更多>>
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Protective effect of lappaconitine on Freund's complete adjuvant-induced arthritis exerted through P2X7 receptor-mediated regulation of M1/M2 balance in rats
《Journal of Traditional Chinese Medicine》2025年第1期39-48,共10页ZHANG Pengqiang FENG Qi HUANG Weiyan OU Shan 
OBJECTIVE:to investigate the anti-arthritic effects of lappaconitine(LA)on adjuvant-induced arthritis in Sprague-Dawley rats and its possible involvement in the regulation of M1/M2 macrophage balance through the P2X7 ...
关键词：arthritis experimental macrophage polarization receptors purinergic P2X7 anti-inflammatory agents ANALGESICS LAPPACONITINE 
Mechanism of dorsal root ganglion SERT in electroacupuncture regulation of P2X3 receptor-mediated visceral hypersensitivity in IBS rats
《Journal of Acupuncture and Tuina Science》2024年第6期435-446,共12页HUANG Rong CHAI Jing ZHOU Yun QIAO Yu WENG Zhijun WU Huangan LIU Huirong ZHU Lu MA Jindan ZHU Yi ZHANG Fang 
上海市青年科技英才扬帆计划项目,No.18YF1421600;上海市自然科学基金项目,No.22ZR1458600;国家自然科学基金面上项目,No.81873367;上海市针灸临床医学研究中心,No.20MC1920500.
Objective:To investigate the role of serotonin reuptake transporter(SERT)and P2X3 receptor of dorsal root ganglion(DRG)in regulating visceral hypersensitivity of rats with irritable bowel syndrome(IBS)by electroacupun...
关键词：Acupuncture Therapy ELECTROACUPUNCTURE Irritable Bowel Syndrome Visceral Hypersensitivity Visceral Pain Receptors Purinergic P2X3 Serotonin Reuptake Transporter RATS 
Adenosine triphosphate mediates the pain tolerance effect of manual acupuncture at Zusanli(ST36) in mice被引量：1
《Journal of Traditional Chinese Medicine》2024年第4期660-669,共10页LI Zhongzheng ZHAO Yadan Ma Weigang Zhang Yonglong XU Zhifang XI Qiang LI Yanqi QIN Siru ZHANG Zichen WANG Songtao ZHAO Xue LIU Yangyang GUO Yi GUO Yongming 
The National Key R&D Program of China:Biological Mechanisms of Acupoint Function-Effect Associations(No.2019YFC1709003);National Natural Science Foundation of China(NSFC)Top-level Project:Study on the Neuroimmunological Mechanism of Macrophage Phenotypic Polarisation for Antiinflammation Regulated by Acupuncture(No.81873369);National Natural Science Foundation of China Young Science Fund Project:Study on the Neuromodulation Mechanism of Electroacupuncture to Improve Neutropenia after Chemotherapy for Lung Cancer(No.81704146);National Natural Science Foundation of China Key Project:Research on the Initial Kinetic Regulation Mechanism of Acupuncture Effect Based on the Physicochemical Coupling Network of Acupuncture Point Microenvironment(No.82030125)。
OBJECTIVE:To investigate the mechanisms behind the effects of acupuncture in Traditional Chinese Medicine,we delved into the adenosine triphosphate/peripheral purinergic P2X receptor 3(ATP/P2X3)receptor signaling syst...
关键词：ACUPUNCTURE point ST36(Zusanli) adenosine triphosphate receptors purinergic P2X3 energy state 
The bumpy road of purinergic inhibitors to clinical application in immune-mediated diseases
《Neural Regeneration Research》2024年第6期1206-1211,共6页Matthias T.Wyss Christine Heuer Marina Herwerth 
supported by the UZH Postdoc grant(to MH);the Foundation for Research in Science at the University of Zurich(to MTW)。
Purinergic signaling plays important roles throughout the body in the regulation of organ functions during and following the disruption of homeostasis.This is also reflected by the widespread expression of two familie...
关键词：autoimmune diseases neurological disorders purinergic system P2 receptor inhibitors SURAMIN 
Effect of electroacupuncture on inflammatory signal expression in local tissues of rats with chronic pelvic pain syndrome based on purinergic 2X7 receptor/NOD-like receptor pyrin domaincontaining 3 signal pathway
《Journal of Traditional Chinese Medicine》2022年第6期965-971,共7页XU Chang LI Na WU Xiaoling DAI Xingye YANG Zhiwen SUN Qianhui SHI Tianyu CHAI Yemao PANG Dandan CHENG Kai 
Supported by Fundamental Research Funds for the Central Universities Project:RNA Sequencing Technology Screening the Mechanism of Acupuncture on Pain in Chronic Pelvic Pain Syndrome Rats (2020-JYB-XJSJJ-018)。
OBJECTIVES: To study the expression of inflammatory signal in local prostate tissue of chronic pelvic pain syndrome(CPPS) rats by electroacupuncture(EA) of Guanyuan(CV4), Zhongji(CV3), Huiyang(BL35) and Sanyinjiao(SP6...
关键词：ELECTROACUPUNCTURE INFLAMMATORY cytokines receptors purinergic P2X7 NLR family pyrin domain-containing 3 protein signal transduction chronic pelvic pain syndrome 
Harpephyllum caffrum stimulates glucose uptake,abates redox imbalance and modulates purinergic and glucogenic enzyme activities in oxidative hepatic injury被引量：1
《Asian Pacific Journal of Tropical Biomedicine》2022年第1期9-19,共11页Kolawole A.Olofinsan Ochuko L.Erukainure Beseni K.Brian Md.Shahidul Islam 
funded by the Research Office,University of KwaZulu-Natal,Durban,and with support from the National Research Foundation-the World Academy of Science(NRF-TWAS),Pretoria,South Africa under(UID:116093).
Objective:To investigate the antioxidative and antidiabetic effects of Harpephyllum caffrum bark infusion as well as its effects on glucogenic and nucleotide hydrolyzing enzyme activities in FeSO4-induced oxidative st...
关键词：Harpephyllum caffrum ANTIOXIDANT Oxidative injury Carbohydrate dysmetabolism 
Regulatory effect of mild moxibustion on P2X3 receptors in spinal cord,anterior cingulate cortex and thalamic ventral posterolateral nucleus of rats with IBS visceral hyperalgesia
《Journal of Acupuncture and Tuina Science》2021年第4期239-248,共10页Zhang Zhi-ying Zhang Fang Weng Zhi-jun Wu Huan-gan Zhou Yun Han Dong Li Guo-na Liu Hui-rong Cui Yun-hua 
上海市卫生和计划生育委员会科研课题,No.20174Y0015;国家自然科学基金项目,No.81904301;973 Program,国家重点基础研究发展计划项目No.2015CB554501;上海中医药事业发展三年行动计划项目,No.ZY(2018–2020)-CCCX-2004-01;国家中医药领军人才支持计划-岐黄学者.
Objective To observe the therapeutic effect of mild moxibustion on irritable bowel syndrome(IBS)visceral hyperalgesia model rats and its regulatory effect on P2X3 receptors in the spinal cord,anterior cingutate cortex...
关键词：Moxibustion Therapy Moxa Stick Moxibustion Irritable Bowel Syndrome Visceral Pain Central Nervous System Sensitization Receptors Purinergic P2X3 Spinal Cord Brain 
Effects of moxibustion on the P2X7R/STAT3/VEGF pathway in rats with colitis-associated colon cancer被引量：1
《Journal of Acupuncture and Tuina Science》2021年第2期83-94,共12页Lin Ya-ying Wang Di Wu Huan-gan Gu Mu-en Li Qi Ma Zhe Huang Yan Lu Yuan Li Kun-shan Wu Lu-yi 
国家自然科学基金项目,No.81774405,No.81973953;上海市卫生和计划生育委员会科研课题,No.20174Y0001;上海市卫生和计划生育委员会卫生行业临床研究专项,No.20184Y0038,No.20184Y0106;上海市卫生系统优秀人才培养计划,No.2018YQ11;上海市自然科学基金课题,No.20ZR1453200。
Objective:To observe the effects of herb-partitioned moxibustion and ginger-partitioned moxibustion on the growth of colon tumors in rats with colitis-associated colon cancer(CACC),and explore the mechanism of moxibus...
关键词：Moxibustion Therapy Medicinal Cake-partitioned Moxibustion Ginger-partitioned Moxibustion Colitis-associated Neoplasms Vascular Endothelial Growth Factor Receptors Purinergic P2X7STAT3 Protein NF-kappa B 
Purinergic Modulation of Activity in the Developing Auditory Pathway被引量：2
《Neuroscience Bulletin》2020年第11期1285-1298,共14页Sasa Jovanovic Ivan Milenkovic 
the Deutsche Forschungsgemeinschaft(DFG Grant 954/3-1)as a part of the priority program 1608“Ultrafast and temporally precise information processing:normal and dysfunctional hearing”。
Purinergic P2 receptors,activated by endogenous ATP,are prominently expressed on neuronal and nonneuronal cells during development of the auditory periphery and central auditory neurons.In the mature cochlea,extracell...
关键词：Purinergic signaling Auditory system DEVELOPMENT COCHLEA Spiral ganglion Auditory brainstem 
Overexpression of Purinergic P2X4 Receptors in Hippocampus Rescues Memory Impairment in Rats with Type 2 Diabetes被引量：3
《Neuroscience Bulletin》2020年第7期719-732,共14页Ping-An Zhang Qian Sun Yong-Chang Li Rui-Xia Weng Rui Wu Hong-Hong Zhang Guang-Yin Xu 
supported by grants from the National Natural Science Foundation of China (31730040,81801115, and 81920108016);the China Postdoctoral Science Foundation (2018M642304);the Priority Academic Program Development of Jiangsu Higher Education Institutions of China。
Purinergic receptors have been reported to be involved in brain disorders.In this study,we explored their roles and mechanisms underlying the memory impairment in rats with type 2 diabetes mellitus(T2 DM).T2 DM rats e...
关键词：MICROGLIA P2X4 receptors DNA damage Type 2 diabetes mellitus Memory impairment 
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