COCHLEA

作品数：144被引量：237H指数：7
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相关领域：医药卫生更多>>
相关作者：李兴启杨军孔维佳林昶杨伟炎更多>>
相关机构：中国人民解放军总医院华中科技大学上海交通大学医学院附属新华医院东南大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金中国博士后科学基金更多>>
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Current AAV-mediated gene therapy in sensorineural hearing loss
《Fundamental Research》2025年第1期192-202,共11页Jieyu Qi Xiaolong Fu Liyan Zhang Fangzhi Tan Nianci Li Qiuhan Sun Xiaojie Hu Zuhong He Ming Xia Renjie Chai 
supported by the National Key Research and Development Program of China(2020YFA0113600,2021YFA1101300,2020YFA0112503);Strategic Priority Research Program of the Chinese Academy of Science(XDA16010303);the National Natural Science Foundation of China(82000984,82030029,81970882,81900937 and 82071013);Natural Science Foundation from Jiangsu Province(BE2019711);the China National Postdoctoral Program for Innovative Talents(BX20200082);the China Postdoctoral Science Foundation(2020M681468);the Science and Technology Department of Sichuan Province(2021YFS0371);Shenzhen Fundamental Research Program(JCYJ20190814093401920,JCYJ20210324125608022);Open Research Fund of State Key Laboratory of Genetic Engineering,Fudan University(SKLGE-2109);the Fundamental Research Funds for the Central Universities.
The number of patients with hearing loss is on the rise due to congenital abnormalities,degenerative changes in old age,and acquired injuries such as virus or ototoxic drug-induced diseases.Hearing loss is a refractor...
关键词：Hearing loss COCHLEA Gene therapy Adeno-associated virus Auditory repair 
Artificial hearing systems based on functional cochlea models
《International Journal of Extreme Manufacturing》2025年第1期73-94,共22页Jinke Chang Sita Tarini Clark Iwan Roberts Filip Hrncirik Zhipeng Zhang Manohar Bance 
support from the UCL GRS/ORS scholarship;UCL Fellowship Incubator Award;supported by the NIHR Cambridge Biomedical Research Centre(NIHR203312);funded by the Royal National Institute for Deaf People(RNID,G100138);funded by the Rosetrees Trust Enterprise Fellowship(EF2020100099);RNID Flexigrant(F112);Wellcome Trust Developing Concept Fund(RG93172/BANCE/40181);by the Evelyn Trust;funded by the Woolf Fisher Trust,New Zealand;the Cambridge Commonwealth,European,&International Trust;by Trinity College;University of Cambridge。
The cochlea is one of the most complex organs in the human body,exhibiting a complex interplay of characteristics in acoustic,mechanical,electrical,and biological functions.Functional cochlea models are an essential p...
关键词：functional cochlea model auditory system hearing loss advanced manufacturing artificial hearing 
Translocation of telomerase reverse transcriptase coincided with ATP release in postnatal cochlear supporting cells被引量：1
《Neural Regeneration Research》2024年第5期1119-1125,共7页Yukai Zhang Keyong Tian Wei Wei Wenjuan Mi Fei Lu Zhenzhen Liu Qingwen Zhu Xinyu Zhang Panling Geng Jianhua Qiu Yongli Song Dingjun Zha 
supported by the National Natural Science Foundation of China,Nos.81870732(to DZ),82171161(to DZ),81900933(to YS),and 82000978(to ZL).
The spontaneous bursts of electrical activity in the developing auditory system are derived from the periodic release of adenosine triphosphate(ATP)by supporting cells in the Kölliker’s organ.However,the mechanisms r...
关键词：apoptosis ATP release Ca2+transients COCHLEA mitochondrial function reactive oxygen species spontaneous electrical activity supporting cells 
Mitochondrial Regulation of Macrophages in Innate Immunity and Diverse Roles of Macrophages During Cochlear Inflammation
《Neuroscience Bulletin》2024年第2期255-267,共13页Yuan Zhang Fanglei Ye Xiaolong Fu Shen Li Le Wang Yutian Chen Hongmin Li Shaojuan Hao Kun Zhao Qi Feng Peipei Li 
supported by the China Postdoctoral Science Foundation(2022M712892);the Joint project Henan Province Medical Science and Technology Project(LHGJ20210297).
Macrophages are essential components of the innate immune system and constitute a non-specific first line of host defense against pathogens and inflammation.Mitochondria regulate macrophage activation and innate immun...
关键词：MACROPHAGE MITOCHONDRIA Innate immunity COCHLEA Infammation 
Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear被引量：1
《Neuroscience Bulletin》2024年第1期113-126,共14页Jieyu Qi Wenjuan Huang Yicheng Lu Xuehan Yang Yinyi Zhou Tian Chen Xiaohan Wang Yafeng Yu Jia-Qiang Sun Renjie Chai 
supported by grants from the National Key R&D Program of China(2021YFA1101300,2021YFA1101800,2020YFA0112503);the National Natural Science Foundation of China(82030029,81970882,82000984,92149304);the Science and Technology Department of Sichuan Province(2021YFS0371);the Shenzhen Fundamental Research Program(JCYJ20190814093401920,JCYJ20210324125608022);the China National Postdoctoral Program for Innovative Talents(BX20200082);the China Postdoctoral Science Foundation(2020M681468);the Open Research Fund of State Key Laboratory of Genetic Engineering,Fudan University(SKLGE-2104).
Hearing loss has become increasingly prevalent and causes considerable disability,thus gravely burdening the global economy.Irreversible loss of hair cells is a main cause of sensorineural hearing loss,and currently,t...
关键词：Hearing loss Cochlea-Stem cell Hair cell regeneration 
Comparing accuracy of cochlear measurements on magnetic resonance imaging and computed tomography:A step towards radiation-free cochlear implantation
《Journal of Otology》2023年第4期208-213,共6页Anurita Swarup Vinusree Karakkandy Preetam Chappity Suprava Naik Sanjay Kumar Behera Pradipta Kumar Parida Mohnish Grover Gaurav Gupta Prajna Paramita Giri Saurav Sarkar Pradeep Pradhan Dillip Kumar Samal Aswathi Kallyadan Veetil Asutosh Adhikari Saurav Nayak 
Objective:Computed Tomography(CT)and Magnetic Resonance Imaging(MRI)are commonly employed in pre-operative evaluation for cochlear implant surgery.However,with a decrease in the age of implantation,even minor radiatio...
关键词：Cochlear implant Hearing loss Cochlea anatomy RADIOLOGY 
Fgf8^(P2A-3×GFP/+):A New Genetic Mouse Model for Specifically Labeling and Sorting Cochlear Inner Hair Cells
《Neuroscience Bulletin》2023年第12期1762-1774,共13页Yi Pan Shuting Li Shunji He Guangqin Wang Chao Li Zhiyong Liu Mingliang Xiang 
funded by the National Key R&D Program of China(2021YFA1101804);the Strategic Priority Research Program of the Chinese Academy of Science(XDB32060100);the National Natural Science Foundation of China(91949119,82101212,and 82101209);a Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);the Science and Technology Commission of Shanghai Municipality(21ZR1440200);the Shanghai Sailing Program(20YF1426400).
The cochlear auditory epithelium contains two types of sound receptors,inner hair cells(IHCs)and outer hair cells(OHCs).Mouse models for labelling juvenile and adult IHCs or OHCs exist;however,labelling for embryonic ...
关键词：Fgf8 Inner Hair Cell Inner Ear-Cochlea 
Lypd1-DTR/+: A New Mouse Model for Specifically Damaging the Type Ic Spiral Ganglion Neurons of the Cochlea
《Neuroscience Bulletin》2023年第9期1459-1462,共4页Di Zhang Minhui Ren ZhengHong Bi Yunpeng Gu Shuting Li Guangqin Wang Xiang Li Zhiyong Liu 
This work was supported by the National Key R&D Program of China(2021YFA1101804);the National Natural Science Foundation of China(82000985 and 82101217);the Strategic Priority Research Program of Chinese Academy of Science(XDB32060100);a Shanghai Municipal Science and Technology Major Project(2018SHZDZX05).
Dear Editor,Inner ear auditory neurons,which are also referred as to spiral ganglion neurons(SGNs),bridge sound-receptor hair cells(HCs)to the cochlear nucleus in the brainstem[1].Two types of SGN exist:type I SGNs(95...
关键词：AUDITORY BRAINSTEM COCHLEAR 
Rassf2 overexpression mediated by AAV promotes the supporting cell-to-hair cell transformation in the cochlea
《Engineered Regeneration》2023年第3期304-315,共12页Liyan Zhang Jieyu Qi Yuan Fang Fangzhi Tan Yinyi Zhou Ziyu Zhang Qiuhan Sun Nianci Li Yideng Huang Jingwu Sun Renjie Chai 
supported by the National Key Research and Development Program of China (2021YFA1101300,2020YFA0112503,2021YFA1101800 and 2020YFA0113600);the National Natural Science Foundation of China (81970882,82030029,92149304,82000984 and 82171146);the China National Postdoctoral Program for Innovative Talents (BX20200082);the China Postdoctoral Science Foundation (2020M681468);the Science and Technology Department of Sichuan Province (2021YFS0371);the Shenzhen Fundamental Research Pro-gram (JCYJ20190814093401920 and JCYJ20210324125608022);the Open Research Fund of State Key Laboratory of Genetic Engineering,Fudan University (SKLGE-2104);2022 Open Project Fund of Guangdong Academy of Medical Sciences to P.N.W. (YKY-KF202201);Key Program of Zhejiang Provincial Natural Science Foundation of China (LZ22H130001).
Sensory hair cells are responsible for detecting and transmitting sound in the inner ear,and damage to HCs leads to hearing loss.HCs do not regenerate spontaneously in adult mammals,which makes the hearing loss perman...
关键词：AAV Rassf2 Hair cell regeneration COCHLEA Organoid 
The overexpression of Rps14 in Lgr5+progenitor cells promotes hair cell regeneration in the postnatal mouse cochlea
《Engineered Regeneration》2023年第3期328-336,共9页Jingru Ai Pei Jiang Jingyuan Huang Hairong Xiao Yanqin Lin Mingchen Dai Yintao Wang Yuan Zhang Mengyao Tian Renjie Chai Shasha Zhang 
supported by the National Key R&D Program of China (No.2021YFA1101300,2021YFA1101800,2020YFA0112503,2022YFA0807000);the Strategic Priority Research Program of the Chinese Academy of Science (XDA16010303);the National Natural Science Foundation of China (Nos.81970892,82171149,82030029,81970882,92149304);the Science and Technology Department of Sichuan Province (No.2021YFS0371);the Shenzhen Fundamental Research Program (JCYJ20190814093401920,JCYJ20210324125608022);the Open Research Fund of the State Key Laboratory of Genetic Engineering,Fudan University (No.SKLGE-2104).
Sensory hair cells(HCs)in the cochlea cannot regenerate spontaneously in adult mammals after being damaged by external or genetic factors.However,several genes and signaling pathways are reported to induce cochlear HC...
关键词：Rps14 Lgr5+progenitor cells Ectopic hair cells Regeneration Proliferation TRANS-DIFFERENTIATION 
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