TRANS-DIFFERENTIATION

作品数：19被引量：54H指数：4
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相关领域：医药卫生更多>>
相关作者：张嘉诚李素停陈会强更多>>
相关机构：浙江大学医学院附属第二医院郑州大学新乡医学院更多>>
相关期刊：《Engineered Regeneration》《Science China(Life Sciences)》《World Journal of Gastroenterology》《中国循环杂志》更多>>
相关基金：国家自然科学基金广东省自然科学基金国家教育部博士点基金国家高技术研究发展计划更多>>
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Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells
《Neural Regeneration Research》2025年第2期598-608,共11页Daniella Da Silva Madeleen Jansen van Rensburg Anine Crous Heidi Abrahamse 
supported by the National Research Foundation(NRF)S&F-Scarce Skills Postdoctoral Fellowship,No.120752(to AC);the Global Excellence and Stature,Fourth Industrial Revolution(GES 4.0)Postgraduate Scholarship(to MJR);the South African Research Chairs Initiative of the Department of Science and Technology and National Research Foundation of South Africa(SARChI/NRF-DST),No.146290(to DDS and HA).
Photobiomodulation,originally used red and near-infrared lasers,can alter cellular metabolism.It has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infr...
关键词：differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease NEUROGENESIS PHOTOBIOMODULATION TRANS-DIFFERENTIATION 
Single-cell transcriptomics reveals neural stem cell trans-differentiation and cell subpopulations in whole heart decellularized extracellular matrix
《Biophysics Reports》2024年第4期241-253,共13页Xiaoning Yang Yuwei Zhao Wei Liu Zhongbao Gao Chunlan Wang Changyong Wang Siwei Li Xiao Zhang 
supported by Youth Talent Fund Project of Military Medical Research Institute(AMMS-QNPY-2021-005);the Joint Fund Project of the National Natural Science Foundation of China(U21A20394);National Natural Science Foundation of China Youth Fund(32201116).
The whole heart decellularized extracellular matrix(ECM)has become a promising scaffold material for cardiac tissue engineering.Our previous research has shown that the whole heart acellular matrix possesses the memor...
关键词：Single-cell transcriptomics Neural stem cell TRANS-DIFFERENTIATION Decellularized extracellular matrix Cardiac lineage cells 
Modeling gastric intestinal metaplasia in 3D organoids using nitrosoguanidine
《Journal of Molecular Cell Biology》2024年第7期46-59,共14页Yuan Li Jiena Chen Tao Li Jie Lin Haocheng Zheng Nadia Johnson Xuebiao Yao Xia Ding 
supported by grants from the National Natural Science Foundation of China(82205095,82374292,92059102,32090040,82204894,and 82305179);the China Postdoctoral Science Foundation(2022M720520);the Anhui TCM Synergism Project(202303a0702003).
Gastric intestinal metaplasia(GIM)represents a precancerous stage characterized by morphological and pathophysiological changes in the gastric mucosa,where gastric epithelial cells transform into a phenotype resemblin...
关键词：gastric organoids MNNG intestinal metaplasia TRANS-DIFFERENTIATION precancerous lesion 
HSFAS mediates fibroblast proliferation, migration, trans-differentiation and apoptosis in hypertrophic scars via interacting with ADAMTS8被引量：3
《Acta Biochimica et Biophysica Sinica》2024年第3期440-451,共12页Fang Ma Honglin Liu Tongtong Xia Zhenghao Zhang Shengchao Ma Yinju Hao Jiangyong Shen Yideng Jiang Nan Li 
This work was supported by the grants from the National Natural Science Foundation of China(No.82360628);the Nonprofit Central Research Institute Fund of the Chinese Academy of Medical Sciences(No.2019PT330002);the Key Research and Development Projects in Ningxia Hui Autonomous Region(No.2022BFH02013).
Hypertrophic scar(HS)is one of the most common sequelae of patients,especially after burns and trauma.The roles of regulatory long noncoding RNAs(lncRNAs)in mediating HS remain underexplored.Human hypertrophic scarder...
关键词：FIBROBLAST HSFAS hypertrophic scar TRANS-DIFFERENTIATION 
The overexpression of Rps14 in Lgr5+progenitor cells promotes hair cell regeneration in the postnatal mouse cochlea
《Engineered Regeneration》2023年第3期328-336,共9页Jingru Ai Pei Jiang Jingyuan Huang Hairong Xiao Yanqin Lin Mingchen Dai Yintao Wang Yuan Zhang Mengyao Tian Renjie Chai Shasha Zhang 
supported by the National Key R&D Program of China (No.2021YFA1101300,2021YFA1101800,2020YFA0112503,2022YFA0807000);the Strategic Priority Research Program of the Chinese Academy of Science (XDA16010303);the National Natural Science Foundation of China (Nos.81970892,82171149,82030029,81970882,92149304);the Science and Technology Department of Sichuan Province (No.2021YFS0371);the Shenzhen Fundamental Research Program (JCYJ20190814093401920,JCYJ20210324125608022);the Open Research Fund of the State Key Laboratory of Genetic Engineering,Fudan University (No.SKLGE-2104).
Sensory hair cells(HCs)in the cochlea cannot regenerate spontaneously in adult mammals after being damaged by external or genetic factors.However,several genes and signaling pathways are reported to induce cochlear HC...
关键词：Rps14 Lgr5+progenitor cells Ectopic hair cells Regeneration Proliferation TRANS-DIFFERENTIATION 
Resolving the lineage relationship between malignant cells and vascular cells in glioblastomas
《Protein & Cell》2023年第2期105-122,共18页Fangyu Wang Xuan Liu Shaowen Li Chen Zhao Yumei Sun Kuan Tian Junbao Wang Wei Li Lichao Xu Jing Jing Juan Wang Sylvia MEvans Zhiqiang Li Ying Liu Yan Zhou 
supported by grants from the National Natural Science Foundation of China(Nos.31970676,31970770,32270876);the National Key R&D Program of China(No.2018 YFA0800700,2022YFA0806600),and the Fundamental Research Funds for the Central Universities.
Glioblastoma multiforme(GBM),a highly malignant and heterogeneous brain tumor,contains various types of tumor and non-tumor cells.Whether GBM cells can trans-differentiate into non-neural cell types,including mural ce...
关键词：GLIOBLASTOMA mural cells endothelial cells TRANS-DIFFERENTIATION lineage tracing single-cell sequencing copy number variation 
Regeneration of β cells from cell phenotype conversion among the pancreatic endocrine cells
《Chronic Diseases and Translational Medicine》2022年第1期1-4,共4页Tianjiao Wei Rui Wei Tianpei Hong 
National Natural Science Foundation of China(81830022 and 81970671)。
The prevalence of diabetes has increased dramatically, with over 537 million adults affected worldwide.1 In both type 1 and type 2 diabetes, pancreatic islet β cell dysfunction is common pathogenesis.
关键词：cell trans-differentiation endocrine pancreas βcell dedifferentiation βcell regeneration 
The role of dendritic cells derived osteoclasts in bone destruction diseases被引量：3
《Genes & Diseases》2021年第4期401-411,共11页Bo Wang Yutong Dong Zhansong Tian Yueqi Chen Shiwu Dong 
This work was supported by grants from the Key Program of Nature Science Foundation of China(grant number 81930067);the Medical Science and Technology Youth Cultivation Project of PLA China(grant number 20QNPY022);Medical innovation capability upgrading Plan of Southwest Hospital China(grant number SWH2018LJ-03);Medical innovation of graduate students in Chongqing China(grant number CYS19360).
The bone is previously considered as a dominant organ involved in the processes of locomotion.However,in the past two decades,a large number of studies have suggested that the skeletal system closely coordinated with ...
关键词：Bone destruction diseases Dendritic cells OSTEOCLASTS OSTEOIMMUNOLOGY TRANS-DIFFERENTIATION 
Massive reorganization of the genome during primary monocyte differentiation into macrophage
《Acta Biochimica et Biophysica Sinica》2020年第5期546-553,共8页Zhipeng Zhang Qi Wang Yulong Liu Qiu Sun Hua Li Daniel M.Czajkowsky Zhifeng Shao 
We thank Yani Kang from School of Biomedical Engineering.Shang-hai Jiao Tong University(Shanghai,China)for useful discussions.Thia work wal upportd by the granta from thc National Kcy R&D Program of Chima(No.2018YFC1003500),the National Natural Science Foundation of China(Nos.11374207,31501054,31670722,31900430,31971151,81627801,and 81972909),and the China Postdoctoral Science Foundation(No.2018M640419).
Monocyte-to-macrophage trans-differentiation has long been studied to better understand this immunological response and aspects of developmentall processes more generally.A key question is the nature of the correspond...
关键词：cellular development contact domains genome architecture TRANS-DIFFERENTIATION 
Complement-mediated perivascular inflammation contributes to hypertensive vascular injury
《中国循环杂志》2018年第S01期123-123,共1页Chengchao Ruan Pingjin Gao 
Adipose tissue plays pivotal roles in the development of hypertension,including white and brown adipocytes.Immunity and inflammation provide a bridge between adipose dysfunction and hypertensive target organ damage.We...
关键词：hypertension PERIVASCULAR ADIPOSE tissue(PVAT) FIBROBLAST migration phenotype TRANS-DIFFERENTIATION 
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