COCHLEAR

作品数：234被引量：327H指数：8
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相关领域：医药卫生更多>>
相关作者：李永新韩德民龚树生韩东一刘莎更多>>
相关机构：首都医科大学复旦大学中国人民解放军总医院上海交通大学医学院附属新华医院更多>>
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Investigating the expression profiles of cysteine string proteins(CSPs)in cochlear tissue
《Journal of Otology》2024年第4期193-199,共7页Shili Zhang Caiji Wang Yuehua Qiao Xi Shi 
supported by the Science and Technology Development aid Project of Xuzhou Science and Technology Bureau(KC21249);supported by Hainan Provincial Natural Science Foundation of China(824MS052);Scientific Research Startup Foundation of Hainan University.
Objective:This study aims to explore the expression patterns of cysteine string protein alpha(CSPα)and cysteine string protein beta(CSPβ)in the mammalian inner ear,with an emphasis on their temporal dynamics during ...
关键词：Cysteine string protein CSPα CSPβ Miniature pig C57BL/6 mouse 
Loss of Fascin2 increases susceptibility to cisplatin-induced hearing impairment and cochlear cell apoptosis in mice
《Journal of Otology》2024年第3期133-139,共7页Yan Wang Yingying Liu Yi Xie Jun Luan Rongrong Liu Yongjia Zhu Ying Ma Yi Fan Yan Sun Wenjing Shang Fengchan Han 
supported by the National Natural Science Foundation of China(No.81771020,81570927 and 81271092);Grant for Scientific and Technological Development Plan for Medical and Health in Shandong Province(2019WS341).
Objectives:Deletion of Fscn2 gene in mice has been linked to progressive hearing loss and degeneration of cochlear cells.Cisplatin,an antitumor drug,can cause various side effects,including ototoxicity.The aim of this...
关键词：Fascin2 CISPLATIN Mouse OTOTOXICITY Apoptosis 
Advance and Application of Single‑cell Transcriptomics in Auditory Research被引量：1
《Neuroscience Bulletin》2024年第7期963-980,共18页Xiangyu Ma Jiamin Guo Mengyao Tian Yaoyang Fu Pei Jiang Yuan Zhang Renjie Chai 
supported by grants from National Key R&D Program of China(2021YFA1101300,2021YFA1101800,2020YFA0112503);Strategic Priority Research Program of the Chinese Academy of Science(XDA16010303);National Natural Science Foundation of China(82030029,81970882,and 92149304);Science and Technology Department of Sichuan Province(2021YFS0371);Shenzhen Fundamental Research Program(JCYJ20190814093401920,JCYJ20210324125608022);Open Research Fund of State Key Laboratory of Genetic Engineering,Fudan University(SKLGE-2104).
Hearing loss and deafness,as a worldwide disability disease,have been troubling human beings.However,the auditory organ of the inner ear is highly heterogeneous and has a very limited number of cells,which are largely...
关键词：Single-cell RNA sequencing Inner ear COCHLEAR Auditory sensory epithelium Spiral ganglion neuron 
Andrographolide Attenuates Noise-Induced Hearing Loss by Ameliorating Cochlear Inflammation
《World Journal of Traditional Chinese Medicine》2024年第2期204-212,共9页Meng-Hua Li Wan-Qi Wang Li-Ting Zheng Meng Bing Chen Yang Chu Miao Qiao Zuo-Li Zhang Konduru Naveena Yong Pan Yun-Shi Zhang He Sun Xiao-Hui Ma Xi Shi 
supported by the Science and Technology Development Aid Project of Xuzhou Science and Technology Bureau(KC21249);the Science and Technology Development Project of Chongqing(CSTB2022NSCQ-M SX1598);Hainan Provincial Natural Science Foundation of China(824MS052);TASLY Special Funding 2023;the Scientific Research Startup Foundation of Hainan University。
Objective:This study aimed to explore andrographolide's mechanism of action and its protective effect on noise-induced hearing loss(NIHL).Materials and Methods:A mice animal model for NIHL was established through expo...
关键词：ANDROGRAPHOLIDE ANTI-INFLAMMATORY auditory protection noise-induced hearing loss traditional Chinese medicine compound 
TMEM63B regulates postnatal development of cochlear sensory epithelia via thyroid hormone signaling
《Journal of Genetics and Genomics》2024年第6期673-676,共4页Chang Ye Tian-Zi Zhang Yan-Yu Zang Yun Stone Shi Guoqiang Wan 
supported by the National Natural Science Foundation of China(82171136 and 81970888 to G.W.,32330044 to Y.S.S.);Fundamental Research Funds for the Central Universities(021414380533toG.W.).
Sound transmission occurs in the cochlea,a complex and ingenious subdivision in the inner ear.The structure of the cochlea develops structurally and functionally by the time before two postnatal weeks(the time of hear...
关键词：COCHLEAR al. SUPPORTING 
Translocation of telomerase reverse transcriptase coincided with ATP release in postnatal cochlear supporting cells被引量：1
《Neural Regeneration Research》2024年第5期1119-1125,共7页Yukai Zhang Keyong Tian Wei Wei Wenjuan Mi Fei Lu Zhenzhen Liu Qingwen Zhu Xinyu Zhang Panling Geng Jianhua Qiu Yongli Song Dingjun Zha 
supported by the National Natural Science Foundation of China,Nos.81870732(to DZ),82171161(to DZ),81900933(to YS),and 82000978(to ZL).
The spontaneous bursts of electrical activity in the developing auditory system are derived from the periodic release of adenosine triphosphate(ATP)by supporting cells in the Kölliker’s organ.However,the mechanisms r...
关键词：apoptosis ATP release Ca2+transients COCHLEA mitochondrial function reactive oxygen species spontaneous electrical activity supporting cells 
Recovery of hearing loss in atypical Meniere’s disease after treatment with orofacial and neck massage: A case report
《World Journal of Otorhinolaryngology》2024年第3期33-40,共8页Kathleen Pillsbury Beth Helm Jeffery J Kuhn 
BACKGROUND A 48-year-old female presented with sudden-onset right-sided aural fullness,low-frequency hearing loss,and tinnitus.Medical history included right-sided tempo-romandibular joint disorder(TMJD)with crepitati...
关键词：Meniere’s disease Temporomandibular joint disorder Cochlear migraine Cochlear hydrops Low-frequency hearing loss Case report 
Mitochondrial Regulation of Macrophages in Innate Immunity and Diverse Roles of Macrophages During Cochlear Inflammation
《Neuroscience Bulletin》2024年第2期255-267,共13页Yuan Zhang Fanglei Ye Xiaolong Fu Shen Li Le Wang Yutian Chen Hongmin Li Shaojuan Hao Kun Zhao Qi Feng Peipei Li 
supported by the China Postdoctoral Science Foundation(2022M712892);the Joint project Henan Province Medical Science and Technology Project(LHGJ20210297).
Macrophages are essential components of the innate immune system and constitute a non-specific first line of host defense against pathogens and inflammation.Mitochondria regulate macrophage activation and innate immun...
关键词：MACROPHAGE MITOCHONDRIA Innate immunity COCHLEA Infammation 
Comparing accuracy of cochlear measurements on magnetic resonance imaging and computed tomography:A step towards radiation-free cochlear implantation
《Journal of Otology》2023年第4期208-213,共6页Anurita Swarup Vinusree Karakkandy Preetam Chappity Suprava Naik Sanjay Kumar Behera Pradipta Kumar Parida Mohnish Grover Gaurav Gupta Prajna Paramita Giri Saurav Sarkar Pradeep Pradhan Dillip Kumar Samal Aswathi Kallyadan Veetil Asutosh Adhikari Saurav Nayak 
Objective:Computed Tomography(CT)and Magnetic Resonance Imaging(MRI)are commonly employed in pre-operative evaluation for cochlear implant surgery.However,with a decrease in the age of implantation,even minor radiatio...
关键词：Cochlear implant Hearing loss Cochlea anatomy RADIOLOGY 
Fgf8^(P2A-3×GFP/+):A New Genetic Mouse Model for Specifically Labeling and Sorting Cochlear Inner Hair Cells
《Neuroscience Bulletin》2023年第12期1762-1774,共13页Yi Pan Shuting Li Shunji He Guangqin Wang Chao Li Zhiyong Liu Mingliang Xiang 
funded by the National Key R&D Program of China(2021YFA1101804);the Strategic Priority Research Program of the Chinese Academy of Science(XDB32060100);the National Natural Science Foundation of China(91949119,82101212,and 82101209);a Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);the Science and Technology Commission of Shanghai Municipality(21ZR1440200);the Shanghai Sailing Program(20YF1426400).
The cochlear auditory epithelium contains two types of sound receptors,inner hair cells(IHCs)and outer hair cells(OHCs).Mouse models for labelling juvenile and adult IHCs or OHCs exist;however,labelling for embryonic ...
关键词：Fgf8 Inner Hair Cell Inner Ear-Cochlea 
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