云南高校图书馆联盟文献共享服务平台- LAPPACONITINE

LAPPACONITINE: 作品数：15被引量：46H指数：3; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：魏孝义张继韦壁瑜王姣姣吴先闯更多>>; 相关机构：西北师范大学中国科学院上海艾韦特医药科技有限公司上海医药工业研究院更多>>; 相关期刊：《Neuroscience Bulletin》《Journal of Chinese Pharmaceutical Sciences》《Journal of Traditional Chinese Medicine》《Chinese Journal of Integrative Medicine》更多>>; 相关基金：国家自然科学基金更多>>

Protective effect of lappaconitine on Freund's complete adjuvant-induced arthritis exerted through P2X7 receptor-mediated regulation of M1/M2 balance in rats: 《Journal of Traditional Chinese Medicine》2025年第1期39-48,共10页ZHANG Pengqiang FENG Qi HUANG Weiyan OU Shan; OBJECTIVE:to investigate the anti-arthritic effects of lappaconitine(LA)on adjuvant-induced arthritis in Sprague-Dawley rats and its possible involvement in the regulation of M1/M2 macrophage balance through the P2X7 ...; 关键词：arthritis experimental macrophage polarization receptors purinergic P2X7 anti-inflammatory agents ANALGESICS LAPPACONITINE

Quantitative Electrophysiological Evaluation of the Analgesic Efficacy of Two Lappaconitine Derivatives: A Window into Antinociceptive Drug Mechanisms: 《Neuroscience Bulletin》2021年第11期1555-1569,共15页Guixiang Teng Fengrui Zhang Zhenjiang Li Chun Zhang Libo Zhang Lele Chen Tao Zhou Lupeng Yue Ji Zhang; This work was supported by the National Natural Science Foundation of China(51873175);the Special Fund of Guiding Scientific and Technological Innovation and Development in Gansu Province,China(2019ZX-05).; Quantitative evaluation of analgesic efficacy improves understanding of the antinociceptive mechanisms of new analgesics and provides important guidance for their development.Lappaconitine(LA),a potent analgesic drug ...; 关键词：ELECTROCORTICOGRAM Analgesic effect Lappaconitine derivatives Antinociceptive mechanisms Laser-evoked potentials

Synthesis, in vitro and in vivo biological evaluation of novel lappaconitine derivatives as potential anti-inflammatory agents被引量：4: 《Acta Pharmaceutica Sinica B》2020年第4期628-645,共18页Lei Pang Chun-Yan Liu Guo-Hua Gong Zhe-Shan Quan; supported by the National Natural Science Foundation of China(No.21662036).; Lappaconitine(LA),a natural compound with a novel C18-diterpenoid alkaloid skeleton,displayed extensive biological profile.Recent research on LA is focused mainly on its anti-tumor and analgesic effects,and therefore ...; 关键词：LAPPACONITINE ANTI-INFLAMMATORY activity NF-KB MAPK Acute LUNG injury PHARMACOKINETIC study

Inhibitory effects of lappaconitine on the neuronal isoforms of voltage-gated sodium channels被引量：2: 《Acta Pharmacologica Sinica》2019年第4期451-459,共9页Yan-fen Li Yue-ming Zheng Yong Yu Yong Gan Zhao-bing Gao; Personalized Medicines "Molecular Signature-Based Drug Discovery and Development"(Strategic Priority Research Program of the Chinese Academy of Sciences, Grant No. XDA12040221 and XDA15050308);the National Natural Science Foundation of China (81603096, 81773707, 61327014, and 61433017),;the Shanghai Science and Technology Innovation Fund 15431901500.; Lappac on itine (LA) has bee n widely used for postoperative and can cer pain control. LA exhibits excellent an algesic activity with a Ion ger effective time tha n comm on local an esthetics such as tetracai ne and b...; 关键词：VOLTAGE-GATED sodium channel 1.7 ANALGESICS LAPPACONITINE TETRACAINE BUPIVACAINE

Lappaconitine solid dispersion monolithic osmotic tablet and lappaconitine push-pull osmotic pump: preparation and comparison of their release performance in vitro被引量：3: 《Journal of Chinese Pharmaceutical Sciences》2017年第6期413-422,共10页吴先闯王姣姣郝海军宋晓勇张永州刘瑜新张红芹; Science and Technology Department of Henan Pro vince Fund Project(Grant No.144300510019); Lappaconitine is a water-insoluble drug, which was used as model drug in this study. Currently, two osmotically controlled delivery systems that are widely used for water-insoluble drug are monolithic osmotic tablet ...; 关键词：LAPPACONITINE Solid dispersion Monolithic osmotic tablet Push-pull osmotic pumps

Study of Analgesic and Anti-inflammatory Effects of Lappaconitine Gelata被引量：32: 《Journal of Traditional Chinese Medicine》2009年第2期141-145,共5页王英姿肖勇庆张超孙秀梅; Objective: To explore the analgesic and anti-inflammatory effects of lappaconitine gelata (LA). Methods: The writhing response induced by acetic acid, the pain response induced by formaldehyde and hot plate method in ...; 关键词：lappaconitine gelata PHARMACODYNAMICS analgesic effect anti-inflammatory effect animal test

Pain management using Han’s acupoint nerve stimulator combined with patient-controlled analgesia following neurosurgery A randomized case control study: 《Neural Regeneration Research》2008年第7期809-812,共4页Junming Ye Zuyu Zhu Cheng Huang Jun Wei; BACKGROUND： Han＇s acupoint nerve stimulator （HANS） has been frequently used to relieve pain by promoting the central nerve system＇s release of endogenous opioid peptides through electric stimulation to the body s...; 关键词：NEUROSURGERY Han＇s acupoint nerve stimulator pain management LAPPACONITINE

Detection and Characterization of Non-covalent Complex between Lappaconitine and β-Cyclodextrin by Electrospray Ionization Tandem Mass Spectrometry: 《Chinese Chemical Letters》2006年第1期65-68,共4页Qing Xuan XU Li LI Hao YUE Zhi Qiang LIU Ming Quart GUO Shu Ying LIU; supported by the National Natural Science Foundation of China(No.30472134,20173057);the State Great Basic Research Project of China(No.2003CCA03100);the Great Research Project of Chinese Academy of Sciences(No.KGCX2-SW-213-06).; The non-covalent complexes between lappaconitine （LA） and β-cyclodextrin （β-CD） have been detected and characterized by electrospray ionization combined with ion trap tandem mass spectrometry （ESI-MSn）. The ex...; 关键词：LAPPACONITINE Β-CYCLODEXTRIN non-covalent complex ESI-MS CID.

DSC and NMR Study on the Inclusion Complex of Lappaconitine with b-Cyclodextrin: 《Chinese Chemical Letters》2002年第3期227-230,共4页Kai Jun LIAO Xiao Hua YAN Dong Yun ZHAO Xue Yi MA; The inclusion complex of lappaconitine (Lap) with b-cyclodextrin (b-CD) has been studied by the differential scanning calorimetry (DSC) and 1H-NMR, 2D-NMR spectroscopy. The structure of the complex has been deduced.; 关键词：Aconitum delphinium LAPPACONITINE b-cyclodextrin inclusion complex DSC NMR.

NaIO_4-Catalyzed Bromination of the Aromatic Ring of Lappaconitine: 《Chinese Chemical Letters》2001年第5期421-424,共4页Qiao Hong CHEN Feng Peng WANG; We thank the National Natural Science Foundation of China(No.30070888);the Chengdu Diao Pharmaceutical Company for support of this work.; Treatment of lappaconitine 1 with NaIO_4 and Br_2-HOAc at room temperature for 7 h afforded smoothly the bromine-containing derivative 4 in 71% yield.; 关键词：Bisnorditerpenoid alkaloid LAPPACONITINE bromination.

LAPPACONITINE