Roles of cADPR and NAADP in pancreatic cells  

作　　者：Yongjuan Zhao Richard Graeff Hon Cheung Lee 

机构地区：[1]Department of Physiology, The University of Hong Kong, Hong Kong, China

出　　处：《Acta Biochimica et Biophysica Sinica》2012年第9期719-729,共11页生物化学与生物物理学报（英文版）

基　　金：This work was supported by the grants from the Council of Hong Kong （Nos. 769107, 768408, 769309 and 770610） and the National Natural Science Foundation of China/the Research Grants Council ofHong Kong （No. N_HKU 722/08）.

摘　　要：Cyclic ADP-ribose （cADPR） and nicotinic acid adenine dinucleotide phosphate （NAADP） are Ca2＋-mobilizing nucleotides that were discovered in the late 1980s. Two decades of investigations have built up a considerable understanding about these two molecules that are related because both are derived from pyridine nucleotides and known to be generated by CD38/ADP-ribosyl cyclases, cADPR has been shown to target the ryanodine receptors in the endoplasmic reticulum whereas NAADP stimulates the two-pore channels in the endo-lysosomes. Accumulating results indicate that cADPR and NAADP are second messenger molecules mediating Ca2＋ signaling activated by a wide range of agonists. This article reviews what is known about these two molecules, especially regarding their signaling roles in the pancreatic cells.Cyclic ADP-ribose （cADPR） and nicotinic acid adenine dinucleotide phosphate （NAADP） are Ca2＋-mobilizing nucleotides that were discovered in the late 1980s. Two decades of investigations have built up a considerable understanding about these two molecules that are related because both are derived from pyridine nucleotides and known to be generated by CD38/ADP-ribosyl cyclases, cADPR has been shown to target the ryanodine receptors in the endoplasmic reticulum whereas NAADP stimulates the two-pore channels in the endo-lysosomes. Accumulating results indicate that cADPR and NAADP are second messenger molecules mediating Ca2＋ signaling activated by a wide range of agonists. This article reviews what is known about these two molecules, especially regarding their signaling roles in the pancreatic cells.

关 键 词：CADPR NAADP ADP-ribosyl cyclase Ca2＋ signaling Ca2＋ store pancreatic acinar cell 

分 类 号：Q26[生物学—细胞生物学] S831.5[农业科学—畜牧学]