乳腺癌转移抑制因子BRMS1研究进展  

Progress on Breast Cancer Metastasis Suppressor 1 (BRMS1)

作　　者：袁圆[1] 朱作言[1] 赖志春[1] 张文霞[1] 

机构地区：[1]北京大学生命科学学院遗传与发育生物学实验室,北京100871

出　　处：《遗传》2006年第9期1141-1148,共8页Hereditas（Beijing)

基　　金：国家自然科学基金(编号:30270186和30510403188)~~

摘　　要：癌转移是导致癌症患者死亡的主要原因,因此,研究癌转移的分子机制能为癌症的预后和治疗提供新的方法。癌转移抑制基因是一类只抑制癌细胞的转移而不影响肿瘤的发生与生长的基因。BRMS1是2000年在乳腺癌细胞中发现的癌转移抑制基因。它所编码的蛋白还可以抑制黑素瘤细胞和小鼠乳腺癌细胞的转移。BRMS1定位于核内,与mSin3-HDAC复合体相互作用,并且可以改变乳腺癌细胞的connexin表达特征,从而恢复间隙连接介导的细胞间连接通讯。文章就BRMS1的研究进展做一综述,对其相关的基因也给予简单的介绍,并对它可能的作用机制进行了预测。Tumour metastasis is a significant contributor to death in cancer patients, So studies on the molecular mechanism of tumor metastasis can provide new prognostic and therapeutic methods. Tumor metastasis suppressor gene is a kind of genes that only suppresses metastasis without affecting tumorigenicity and tumor growth. BFIMS1 is a tumor metastasis suppressor gene discovered in breast carcinoma cells in 2000. Its protein product was found to also suppress metastasis of melanoma cells and murine mammary carcinoma cells. BRMS1 is located in the nucleus,and interacts with mSin3-HDAC complex, and can alter the connexin expression profile of breast carcinoma cells, thereby restoring ceU-ceU communication via gap junctions. This review highlights some recent progress in the study of BRMSl, gives a brief introduction of related genes, and predicts its possible mechanism of action.

关 键 词：癌转移抑制基因 BRMS1 CONNEXIN mSin3-HDAC复合体 ER 

分 类 号：R737.9[医药卫生—肿瘤]