CONNEXIN

作品数：113被引量：263H指数：8
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Integrative analyses identified gap junction beta‐2 as a prognostic biomarker and therapeutic target for breast cancer
《Cancer Innovation》2024年第4期43-56,共14页Di Zhang Lixi Li Fei Ma 
Background:Increasing evidence has shown that connexins are involved in the regulation of tumor development,immune escape,and drug resistance.This study investigated the gene expression patterns,prognostic values,and ...
关键词：breast cancer CONNEXIN gap junction beta‐2 phosphoinositide 3‐kinase‐Akt‐mTOR pathway prognosis 
Hidrotic ectodermal dysplasia in a Chinese pedigree:A case report
《World Journal of Clinical Cases》2023年第6期1403-1409,共7页Ming-Yi Liao Hui Peng Long-Nian Li Tao Yang Shi-Yin Xiong Xiao-Ying Ye 
BACKGROUND We report on a large family of Chinese Han individuals with hidrotic ectodermal dysplasia(HED)with a variation in GJB6(c.31G>A).The patients in the family had a triad of clinical manifestations of varying d...
关键词：Hidrotic ectodermal dysplasia GJB6 CONNEXIN Gene sequencing Cell transfection Case report 
Effect of Cx32 over‑expression on cell proliferation, migration, and invasion of hepatocellular carcinoma cell line Huh7 and its mechanism
《Journal of Hainan Medical University》2023年第2期35-42,共8页JI Wen‑bin LV Zhen‑yu CHENG Qian‑qian ZHOU Xue‑li WANG Wei YANG Yan 
National Natural Science Foundation of China(No.81402514);Support Program for Excellent Young Talents in Universities of Anhui Province(No.gxyq2022042);"512 Talent Cultivation Plan" of Bengbu Medical College(No.by51202208)。
Objective: To explore the effect of connexin 32 (Cx32) on the cell proliferation, migration, invasion of human hepatocellular carcinoma (HCC) cell line Huh7 and its mechanism. Methods: Firstly, bioinformatics techniqu...
关键词：Hepatocellular carcinoma Connexin 32 Proliferation MIGRATION INVASION Epithelial⁃mesenchymal transition 
Connexin亚细胞定位与肿瘤发生发展关系的研究进展
《中国药理学通报》2022年第8期1132-1136,共5页莫孝成 沈小菊 莫小香 于菲 何敬川 谭惟丹 邓志华 陈志泉 阳洁 
国家自然科学基金资助项目(No.82160698,81860649);广西自然科学基金(No.2018GXNSFAA050053);广西药学一流学科项目(No.GXFCDP-PS-2018)。
缝隙连接蛋白(connexin,Cx)是一个多基因编码的跨膜蛋白家族,能够在细胞膜上组成缝隙连接通道(gap junction,GJ)和半通道(hemichannel,HC),介导细胞之间、细胞质与细胞外环境之间的通讯功能,或在细胞质中通过羧基端与其他蛋白分子相互作...
关键词：缝隙连接通道 缝隙连接蛋白 肿瘤 亚细胞定位 翻译后修饰 治疗靶点 
Connexin蛋白在老年性耳聋中作用的研究进展被引量：3
《中华耳科学杂志》2022年第2期339-343,共5页杨泽垠 曲雁 
河北省自然基金面上项目(H2019206413)~~。
随着社会老龄化的不断加快,老年性耳聋(年龄相关性听力损失)的发病率越来越高。它严重影响老年人的生活质量,还可能导致社会孤立、抑郁,甚至痴呆。老年性耳聋是一种极其复杂的多基因和多因素疾病。Connexin蛋白在内耳发育和维持正常听...
关键词：老年性耳聋 连接蛋白 连接蛋白26 
The role of gap junctions in cell death and neuromodulation in the retina
《Neural Regeneration Research》2021年第10期1911-1920,共10页Gergely Szarka Marton Balogh Adam J.Tengolics Alma Ganczer Bela Volgyi Tamas Kovacs-Oller 
This work was supported by the Hungarian Brain Research Program 2(2017-1.2.1.-NKP-2017)(to BV),by the NKFI(OTKA NN128293);from the European Union and the State of Hungary,co-financed by the European Social Fund in the framework of TAMOP-4.2.4.A/2-11/1-2012-0001 National Excellence Program(to BV);by the UNKP-20-3-I-PTE-472 New National Excellence Program of the Ministry for Innovation and Technology(to GS).
Vision altering diseases,such as glaucoma,diabetic retinopathy,age-related macular degeneration,myopia,retinal vascular disease,traumatic brain injuries and others cripple many lives and are projected to continue to c...
关键词：age-related macular degeneration bystander effect CONNEXIN diabetic retinopathy gap junction GLAUCOMA NEUROMODULATION RETINA retinal disease VISION 
Mechanotransduction via the coordinated actions of integrins,PI3K signaling and Connexin hemichannels被引量：9
《Bone Research》2021年第1期86-96,共11页Manuel A.Riquelme Sumin Gu Rui Hua Jean X.Jiang 
the National Institutes of Health(NIH)grant AR072072(to J.X.J.);the Welch Foundation grant AQ-1507(to J.X.J.).We also thank the UTHSCSA CMMI and the UTHSCSA Optical Imaging Facility supported by the Cancer Therapy and Research Center for the support provided from the NIH-National Cancer Institute P30 award CA054174 and Texas state funds.
Mechanical loading opens connexin 43(Cx43)hemichannels(HCs),leading to the release of bone anabolic molecules,such as prostaglandins,from mechanosensitive osteocytes,which is essential for bone formation and remodelin...
关键词：PI3K/AKT stimulation COORDINATED 
Connexin therapeutics:blocking connexin hemichannel pores is distinct from blocking pannexin channels or gap junctions被引量：1
《Neural Regeneration Research》2021年第3期482-488,共7页Monica L.Acosta Mohd N.Mat Nor Cindy X.Guo Odunayo O.Mugisho Frazer P.Coutinho Ilva D.Rupenthal Colin R.Green 
supported in part by New Zealand Lottery Health Research;the Maurice and Phyllis Paykel Trust;the New Zealand Optometric Vision Research Foundation。
Compounds that block the function of connexin and pannexin protein channels have been suggested to be valuable therapeutics for a range of diseases.Some of these compounds are now in clinical trials,but for many of th...
关键词：CONNEXIN gap junction gap19 HEMICHANNEL PANNEXIN retina tonabersat 
Connexin 36 Mediates Orofacial Pain Hypersensitivity Through GluK2 and TRPA1被引量：1
《Neuroscience Bulletin》2020年第12期1484-1499,共16页Qian Li Tian-Le Ma You-Qi Qiu Wen-Qiang Cui Teng Chen Wen-Wen Zhang Jing Wang Qi-Liang Mao-Ying Wen-Li Mi Yan-Qing Wang Yu-Xia Chu 
the National Natural Science Foundation of China(81971056,31600852,81771202,and 81873101);the Innovative Research Team of Highlevel Local Universities in Shanghai;the Foundation of Science,Technology and Innovation Commission of Shenzhen Municipality(JCYJ20180302153701406);the National Key R&D Program of China(2017YFB0403803);the Shanghai Municipal Science and Technology Major Project(2018SHZDZX01);ZJLab。
Trigeminal neuralgia is a debilitating condition,and the pain easily spreads to other parts of the face.Here,we established a mouse model of partial transection of the infraorbital nerve(pT-ION)and found that the Conn...
关键词：Orofacial pain Gap junction Glutamate receptor ionotropic kainate 2 Transient receptor potential A1 
Tumor-suppressor microRNA-139-5p restrains bladder cancer cell line ECV-304 properties via targeting Connexin 43被引量：1
《Chinese Medical Journal》2019年第19期2354-2361,共8页Qiang Chi Zhi-Yong Wang Hong-Yang Li Dian-Bin Song Hui Xu Guang Ma Ze-Min Wang Xiu-Ming Li 
Background:In our previous paper,we demonstrated that Connexin 43(CX43)was highly expressed in bladder cancer(BC)tissues.But the molecular mechanism about microRNAs(miRNAs)regulation upstream of CX43 in BC has not bee...
关键词：BLADDER cancer CONNEXIN 43 MICRORNAS 
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