The role of gap junctions in cell death and neuromodulation in the retina  

作　　者：Gergely Szarka Marton Balogh Adam J.Tengolics Alma Ganczer Bela Volgyi Tamas Kovacs-Oller 

机构地区：[1]Janos Szentagothai Research Centre,University of Pecs,Pecs,Hungary [2]Retinal Electrical Synapses Research Group,National Brain Research Program(NAP 2.0),Hungarian Academy of Sciences,Budapest,Hungary [3]Department of Experimental Zoology and Neurobiology,University of Pecs,Pecs,Hungary [4]Medical School,University of Pecs,Pecs,Hungary

出　　处：《Neural Regeneration Research》2021年第10期1911-1920,共10页中国神经再生研究（英文版）

基　　金：This work was supported by the Hungarian Brain Research Program 2(2017-1.2.1.-NKP-2017)(to BV),by the NKFI(OTKA NN128293);from the European Union and the State of Hungary,co-financed by the European Social Fund in the framework of TAMOP-4.2.4.A/2-11/1-2012-0001 National Excellence Program(to BV);by the UNKP-20-3-I-PTE-472 New National Excellence Program of the Ministry for Innovation and Technology(to GS).

摘　　要：Vision altering diseases,such as glaucoma,diabetic retinopathy,age-related macular degeneration,myopia,retinal vascular disease,traumatic brain injuries and others cripple many lives and are projected to continue to cause anguish in the foreseeable future.Gap junctions serve as an emerging target for neuromodulation and possible regeneration as they directly connect healthy and/or diseased cells,thereby playing a crucial role in pathophysiology.Since they are permeable for macromolecules,able to cross the cellular barriers,they show duality in illness as a cause and as a therapeutic target.In this review,we take recent advancements in gap junction neuromodulation(pharmacological blockade,gene therapy,electrical and light stimulation)into account,to show the gap junction’s role in neuronal cell death and the possible routes of rescuing neuronal and glial cells in the retina succeeding illness or injury.

关 键 词：age-related macular degeneration bystander effect CONNEXIN diabetic retinopathy gap junction GLAUCOMA NEUROMODULATION RETINA retinal disease VISION 

分 类 号：R774.1[医药卫生—眼科]