PANNEXIN

作品数：27被引量：42H指数：4
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相关领域：医药卫生更多>>
相关作者：马艳罗本燕肖波姜婷肖霞更多>>
相关机构：中南大学浙江大学浙江大学医学院附属第一医院复旦大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《生理科学进展》《International Journal of Ophthalmology(English edition)》《神经损伤与功能重建》更多>>
相关基金：国家自然科学基金国家教育部博士点基金上海市自然科学基金上海市青年科技启明星计划更多>>
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MSCs-derived apoptotic extracellular vesicles promote muscle regeneration by inducing Pannexin 1 channel-dependent creatine release by myoblasts被引量：1
《International Journal of Oral Science》2023年第1期63-75,共13页Qingyuan Ye Xinyu Qiu Jinjin Wang Boya Xu Yuting Su Chenxi Zheng Linyuan Gui Lu Yu Huijuan Kuang Huan Liu Xiaoning He Zhiwei Ma Qintao Wang Yan Jin 
supported by the National Key Research and Development Program of China(2021YFA1100600);National Natural Science Foundation of China(82170955,32101096,and 32100953);Shaanxi Provincial Key Research and Development Plan Project(2022SF-095);the Youth Talent Training Project for School of Stomatology in Fourth Military Medical University(2020QNYC01)。
Severe muscle injury is hard to heal and always results in a poor prognosis.Recent studies found that extracellular vesicle-based therapy has promising prospects for regeneration medicine,however,whether extracellular...
关键词：APO extracellular RELEASE 
Plasma and aqueous humor levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy被引量：5
《International Journal of Ophthalmology(English edition)》2022年第3期453-460,共8页Fatih Cem Gül Sabiha Güngör Kobat FatihÇelik Süleyman Aydin Ramazan Fazil Akkoç 
AIM: To evaluate plasma and aqueous levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy.METHODS: The study included three age and gendermatched groups of 20 cataract patients with no...
关键词：diabetes mellitus RETINOPATHY adiponutrin pannexin 1 
Caspase-11 promotes NLRP3 inflammasome activation via the cleavage of pannexin1 in acute kidney disease被引量：6
《Acta Pharmacologica Sinica》2022年第1期86-95,共10页Fan Yin Pei-qing Zheng Liu-qi Zhao Yan-zhe Wang Nai-jun Miao Zhuan-li Zhou Qian Cheng Pan-pan Chen Hong-yan Xie Jing-yao Li Jia-yun Ni Li Zhou Wei Zhang Xiao-xia Wang Jun Liu Li-min Lu 
This research was financially supported by the National Natural Science Foundation of China(No.82070712,81873603,81670664)to LML,and(No.81873603)to XXW.The authors would like to thank the research participants for volunteering their time in the study.
Ischemia/reperfusion(I/R)injury is a major cause of acute kidney injury(AKI)in clinic.The activation of NLRP3 inflammasome is associated with inflammation and renal injury in I/R-induced AKI.In the current study we ex...
关键词：acute kidney injury ischemia/reperfusion injury caspase-11 NLRP3 inflammasome pannexin 1 P2X7 receptor ATP primary tubular cells NRK-52E cells CARBENOXOLONE AZD9056 
Pannexin 1,a large-pore membrane channel,contributes to hypotonicity-induced ATP release in Schwann cells被引量：3
《Neural Regeneration Research》2021年第5期899-904,共6页Zhong-Ya Wei Hui-Lin Qu Yu-Juan Dai Qian Wang Zhuo-Min Ling Wen-Feng Su Ya-Yu Zhao Wei-Xing Shen Gang Chen 
This study was supported by the National Natural Science Foundation of China,Nos.31900718(to ZYW),31872773(to GC);the National Key Research and Development Program of China,No.2017YFA0104704(to GC);Basic Research Program of the Education Department of Jiangsu Province of China,Nos.19KJB180024(to ZYW),18KJB180020(to WXS);Postdoctoral Science Foundation of China,No.2019M651925(to ZYW),Jiangsu Students’Platform for Innovation and Entrepreneurship Training Program of China,No.201810304031Z(to YJD);Six Talent Peaks Project in Jiangsu Province of China,No.WSN-007(to WXS).
Pannexin 1(Panx 1),as a large-pore membrane channel,is highly permeable to ATP and other signaling molecules.Previous studies have demonstrated the expression of Panx 1 in the nervous system,including astrocytes,micro...
关键词：ATP CYTOSKELETON injury neuron pannexin 1 peripheral nerve Ras homolog family member A Schwann cells 
Connexin therapeutics:blocking connexin hemichannel pores is distinct from blocking pannexin channels or gap junctions被引量：1
《Neural Regeneration Research》2021年第3期482-488,共7页Monica L.Acosta Mohd N.Mat Nor Cindy X.Guo Odunayo O.Mugisho Frazer P.Coutinho Ilva D.Rupenthal Colin R.Green 
supported in part by New Zealand Lottery Health Research;the Maurice and Phyllis Paykel Trust;the New Zealand Optometric Vision Research Foundation。
Compounds that block the function of connexin and pannexin protein channels have been suggested to be valuable therapeutics for a range of diseases.Some of these compounds are now in clinical trials,but for many of th...
关键词：CONNEXIN gap junction gap19 HEMICHANNEL PANNEXIN retina tonabersat 
Pannexin-2,a novel mitochondrial-associated membrane protein,may become the new strategy to treat and prevent neurological disorders被引量：2
《Acta Biochimica et Biophysica Sinica》2020年第10期1178-1180,共3页Yiyuan Yang Li Wang Linxi Chen Lanfang Li 
This work was supported by the grants from the National Natu-ral Science Foundation of China(Nos.81670265 and 81970431);Innovation Platform Open Foundation of Education Department of Hunan Province(No.18K073);Hunan Provincial Science and Technology Department Document(No.2019-56).
Connexins and pannexins are two kinds of transmembrane pro-teins,which play important physiological roles.Connexins form hemichannels and channels,mainly contributing to the formation of gap junctions.Pannexins are ne...
关键词：NEUROLOGICAL PANNEXIN contributing 
过表达Pannexin 3对急性牙髓炎模型大鼠牙髓组织炎症反应的作用被引量：4
《局解手术学杂志》2020年第10期769-773,共5页曾宁碧 熊宇 赵希 曾旖 黄文静 叶艳艳 
教育部留学回国人员科研启动基金(HG2015-002);院级军队科研基金(SWH2016JSTSYB-40N)。
目的探讨过表达Pannexin 3对急性牙髓炎模型大鼠牙髓组织炎症反应的作用及其机制。方法选取40只健康雄性SD大鼠,其中10只作为对照组,其余30只建立急性牙髓炎大鼠模型,随机分为模型组、抑制组、过表达组,每组10只。采用Western blot法检...
关键词：急性牙髓炎 牙髓组织 炎症反应 损伤修复 大鼠模型 泛连接蛋白3 
Astrocytic modulation of potassium under seizures被引量：1
《Neural Regeneration Research》2020年第6期980-987,共8页Fushun Wang Xiaoming Qi Jun Zhang Jason HHuang 
supported partially by Helen Vosburg Mc Crillus Plummer;Robert Edward Lee Plummer,Jr.Chair in Neurosurgery(to JHH);NIH-R01-NS-067435(to JHH)
The contribution of an impaired astrocytic K^+ regulation system to epileptic neuronal hyperexcitability has been increasingly recognized in the last decade.A defective K^+ regulation leads to an elevated extracellula...
关键词：AQP4 Ca^2+ signaling cell volume CONNEXINS epilepsy K^+ BUFFERING mi RNA NKCC PANNEXIN TBI 
Structural basis for gating mechanism of Pannexin 1 channel被引量：3
《Cell Research》2020年第5期452-454,共3页Luqiu Mou Meng Ke Mengxiao Song Yuanyue Shan Qingjie Xiao Qingting Liu Jialu Li Ke Sun Lei Pu Li Guo Jia Geng Jianping Wu Dong Deng 
This work was supported by funds from National Key R&D Program of China(2016YFA0502700);Sichuan Youth Science and Technology Foundation(2017JQ0007).
Dear Editor,Pannexin 1(PANX1)plays extensive physiological roles across diverse fields of biology,including cell death,1,2 inflammation,3 cancer progression,4 and neurological disorders.5 As suggested by biochemical a...
关键词：INFLAMMATION MECHANISM CHANNEL 
Cryo-EM structure of human heptameric Pannexin 1 channel被引量：6
《Cell Research》2020年第5期446-448,共3页Ronggui Qu Lili Dong Jilin Zhang Xuekui Y u Lei Wang Shujia Zhu 
This work was financially supported by the National Key R&D Program of China(2017YFA0505700,2016YFC1000600,2017YFC1001500,2018YFC1003800);the National Natural Science Foundation of China(31771115,81725006,81822019,81771581,81571501,81971450,81971382);the Strategic Priority Research Program of the Chinese Academy of Science(XDB32020000,XDA12010317);the Shanghai Municipal Science and Technology Major Project(2018SHZDZX05,2017SHZDZX01);the CAS Key Laboratory of Receptor Research(SIMM1804YKF-03);the Thousand Young Talents Program,the 100 Talents Program of the Chinese Academy of Sciences,the Natural Science Foundation of Shanghai(18ZR1447700);Shanghai Rising-Star Program(grant 17QA1404800).
Dear Editor,Cellular communication is crucial during basic development and in the maintenance of homeostasis in adult organisms,and such communication involves the connexin and pannexin(PANX)families of large-pore cha...
关键词：HOMEOSTASIS RELEASE ISCHEMIA 
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