supported partially by Helen Vosburg Mc Crillus Plummer;Robert Edward Lee Plummer,Jr.Chair in Neurosurgery(to JHH);NIH-R01-NS-067435(to JHH)
The contribution of an impaired astrocytic K^+ regulation system to epileptic neuronal hyperexcitability has been increasingly recognized in the last decade.A defective K^+ regulation leads to an elevated extracellula...
This work was supported by grants from the Canadian Institutes for Health Research(MOP-81392)(S.N.O.);Russian Foundation for Fundamental Research##14-04-31705(S.V.K.),15-04-00101(S.N.O.);the Russian Scientific Foundation#14-15-00006(S.N.O.);the USA National Institutes of Health Award R01-GM85058(N.O.D.).
This review summarizes the data on the functional significance of ubiquitous(NKCC1)and renal-specific(NKCC2)isoforms of electroneutral sodium,potassium and chloride cotransporters.These carriers contribute to the path...