BACKGROUND Inflammatory bowel disease(IBD)constitutes a substantial risk factor for colorectal cancer.Connexin 43(Cx43)is a protein that forms gap junction(GJ)complexes involved in intercellular communication,and its ...
supported partially by Helen Vosburg Mc Crillus Plummer;Robert Edward Lee Plummer,Jr.Chair in Neurosurgery(to JHH);NIH-R01-NS-067435(to JHH)
The contribution of an impaired astrocytic K^+ regulation system to epileptic neuronal hyperexcitability has been increasingly recognized in the last decade.A defective K^+ regulation leads to an elevated extracellula...
supported by the “New Xiangya Talent Projects” of the Third Xiangya Hospital of Central South University (JY201710)
Helicobacter pylori (H. pylori) is a Gram-negative bacterium with a number of virulence factors, such as cytotoxin-associated gene A, vacuolating cytotoxin A, its pathogenicity island, and lipopolysaccharide, which ca...
the Russian Science Foundation (Grant # 18-15-00254).
Connexins family in humans consists of 21 highly conserved proteins that are responsible for contact formation between cells. On the cell surface, connexins form hemichannels, or connexons. Two hemichannels brought to...
supported by NIH grant R01EY012857(JO);the Frederic B.Asche endowment and Research to Prevent Blindness.KBM is supported by T32EY007024
Both neurons and glia throughout the central nervous system are organized into networks by gap junctions. Among glia, gap junctions facilitate metabolic homeostasis and intercellular communication. Among neurons, gap ...