supported by National Key R&D Program of China(2019YFA0111900,2023YFB4606705);National Natural Science Foundation of China(No.82072506,82272611,92268115,82302764);Hunan Provincial Science Fund for Distinguished Young Scholars(No.2024JJ2089);Science and Technology Innovation Program of Hunan Province(No.2021RC3025,2023SK2024);Provincial Natural Science Foundation of Hunan(No.2022JJ70162,2023JJ30949);National Clinical Research Center for Geriatric Disorders(Xiangya Hospital,Grant No.2021KFJJ02 and 2021LNJJ05);National Clinical Research Center for Orthopedics,Sports Medicine and Rehabilitation(2021-NCRC-CXJJ-PY-40).
During cell differentiation,growth,and development,cells can respond to extracellular stimuli through communication channels.Pannexin(Panx)family and connexin(Cx)family are two important types of channel-forming prote...