Pannexins in the musculoskeletal system:new targets for development and disease progression  

作　　者：Yan Luo Shengyuan Zheng Wenfeng Xiao Hang Zhang Yusheng Li 

机构地区：[1]Department of Orthopedics,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China [2]National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China [3]Department of Clinical Medicine,Xiangya Medicine School,Central South University,Changsha,Hunan 410008,China [4]Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China

出　　处：《Bone Research》2024年第2期255-269,共15页骨研究（英文版）

基　　金：supported by National Key R&D Program of China(2019YFA0111900,2023YFB4606705);National Natural Science Foundation of China(No.82072506,82272611,92268115,82302764);Hunan Provincial Science Fund for Distinguished Young Scholars(No.2024JJ2089);Science and Technology Innovation Program of Hunan Province(No.2021RC3025,2023SK2024);Provincial Natural Science Foundation of Hunan(No.2022JJ70162,2023JJ30949);National Clinical Research Center for Geriatric Disorders(Xiangya Hospital,Grant No.2021KFJJ02 and 2021LNJJ05);National Clinical Research Center for Orthopedics,Sports Medicine and Rehabilitation(2021-NCRC-CXJJ-PY-40).

摘　　要：During cell differentiation,growth,and development,cells can respond to extracellular stimuli through communication channels.Pannexin(Panx)family and connexin(Cx)family are two important types of channel-forming proteins.Panx family contains three members(Panx1-3)and is expressed widely in bone,cartilage and muscle.Although there is no sequence homology between Panx family and Cx family,they exhibit similar configurations and functions.Similar to Cxs,the key roles of Panxs in the maintenance of physiological functions of the musculoskeletal system and disease progression were gradually revealed later.Here,we seek to elucidate the structure of Panxs and their roles in regulating processes such as osteogenesis,chondrogenesis,and muscle growth.We also focus on the comparison between Cx and Panx.As a new key target,Panxs expression imbalance and dysfunction in muscle and the therapeutic potentials of Panxs in joint diseases are also discussed.

关 键 词：SKELETAL DISEASES SYSTEM 

分 类 号：R68[医药卫生—骨科学]