Pannexins蛋白在颞叶癫痫患者脑组织中的表达及临床意义  

Over-expression of Pannexins Protein in Brain of Patients with Temporal Lobe Epilepsy

作　　者：马艳[1,2] 姜婷[1] 肖波[1] 曾畅[1] 秦冰[1] 李业[1] 

机构地区：[1]中南大学湘雅医学院神经内科,长沙410008 [2]岳阳市一人民医院神经内科,湖南岳阳414000

出　　处：《神经损伤与功能重建》2011年第3期166-171,共6页Neural Injury and Functional Reconstruction

摘　　要：目的:观察颞叶癫痫患者脑组织Pannexins蛋白(Panx1、Panx2)的表达,探索其在颞叶癫痫发病机制中的作用。方法:收集32例颞叶癫痫患者(实验组)和7例无癫痫病史的手术患者(对照组)的颞叶脑组织,采用免疫组化方法研究2组脑组织中的Panx1、Panx2蛋白的表达。结果:实验组与对照组比较,Panx1、Panx2表达水平均升高,差异具有统计学意义(P<0.05),颞叶皮质神经元的胞体可见Panx1、Panx2的表达。结论:Panx1、Panx2在颞叶癫痫患者颞叶组织中表达升高,提示它们可能在颞叶癫痫发病机制中起重要作用。Objective： To study the expression of pannexins protein （Panxl.Panx2） in the brain tissue of patients with temporal lobe epilepsy （TLE） and its possible role in the pathogenesis of TLE. Methods： Immunohistochemistry was used to detect the expression of Panxl and Panx2 in the surgically removed brain tissue of patients with TLE （n=32）, and the results were compared with that of control tissue （n：7）. Results： Panxl and Panx2 expressions were significantly increased in the temporal lobe cortex of the patients with TLE when compared to those in controls in the same regions（P〈0.05）. Conclusion： The expressions of Panxl and Panx2 were up-regulated in the cortex of the temporal lobe which may be involved in the pathophysiology of temporal lobe epilepsy.

关 键 词：PANNEXINS 颞叶癫痫 免疫组织化学 

分 类 号：R741[医药卫生—神经病学与精神病学] R742.1[医药卫生—临床医学]