How does Helicobacter pylori cause gastric cancer through connexins: An opinion review  

作　　者：Huan Li Can-Xia Xu Ren-Jie Gong Jing-Shu Chi Peng Liu Xiao-Ming Liu 

机构地区：[1]Department of Gastroenterology, the Third Xiangya Hospital of Central South University

出　　处：《World Journal of Gastroenterology》2019年第35期5220-5232,共13页世界胃肠病学杂志（英文版）

基　　金：supported by the “New Xiangya Talent Projects” of the Third Xiangya Hospital of Central South University (JY201710)

摘　　要：Helicobacter pylori (H. pylori) is a Gram-negative bacterium with a number of virulence factors, such as cytotoxin-associated gene A, vacuolating cytotoxin A, its pathogenicity island, and lipopolysaccharide, which cause gastrointestinal diseases. Connexins function in gap junctional homeostasis, and their downregulation is closely related to gastric carcinogenesis. Investigations into H. pylori infection and the fine-tuning of connexins in cells or tissues have been reported in previous studies. Therefore, in this review, the potential mechanisms of H. pylori-induced gastric cancer through connexins are summarized in detail.Helicobacter pylori(H. pylori) is a Gram-negative bacterium with a number of virulence factors, such as cytotoxin-associated gene A, vacuolating cytotoxin A,its pathogenicity island, and lipopolysaccharide, which cause gastrointestinal diseases. Connexins function in gap junctional homeostasis, and their downregulation is closely related to gastric carcinogenesis. Investigations into H.pylori infection and the fine-tuning of connexins in cells or tissues have been reported in previous studies. Therefore, in this review, the potential mechanisms of H. pylori-induced gastric cancer through connexins are summarized in detail.

关 键 词：HELICOBACTER pylori CONNEXIN GAP JUNCTIONAL INTERCELLULAR communications GAP junction proteins Gastric cancer Transcription factors DNA methylation Proliferation Apoptosis 

分 类 号：R[医药卫生]