CARBENOXOLONE

作品数：8被引量：20H指数：3
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相关领域：医药卫生更多>>
相关作者：江山高蓓饶志仁段丽熊鹰飞更多>>
相关机构：第四军医大学北京大学更多>>
相关期刊：《Asian Journal of Pharmaceutical Sciences》《Neuroscience Bulletin》《Acta Pharmacologica Sinica》《Neural Regeneration Research》更多>>
相关基金：国家自然科学基金湖北省自然科学基金更多>>
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Caspase-11 promotes NLRP3 inflammasome activation via the cleavage of pannexin1 in acute kidney disease被引量：6
《Acta Pharmacologica Sinica》2022年第1期86-95,共10页Fan Yin Pei-qing Zheng Liu-qi Zhao Yan-zhe Wang Nai-jun Miao Zhuan-li Zhou Qian Cheng Pan-pan Chen Hong-yan Xie Jing-yao Li Jia-yun Ni Li Zhou Wei Zhang Xiao-xia Wang Jun Liu Li-min Lu 
This research was financially supported by the National Natural Science Foundation of China(No.82070712,81873603,81670664)to LML,and(No.81873603)to XXW.The authors would like to thank the research participants for volunteering their time in the study.
Ischemia/reperfusion(I/R)injury is a major cause of acute kidney injury(AKI)in clinic.The activation of NLRP3 inflammasome is associated with inflammation and renal injury in I/R-induced AKI.In the current study we ex...
关键词：acute kidney injury ischemia/reperfusion injury caspase-11 NLRP3 inflammasome pannexin 1 P2X7 receptor ATP primary tubular cells NRK-52E cells CARBENOXOLONE AZD9056 
Dependence of Generation of Hippocampal CAI Slow Oscillations on Electrical Synapses被引量：1
《Neuroscience Bulletin》2020年第1期39-48,共10页Yuan Xu Feng-Yan Shen Yu-Zhang Liu Lidan Wang Ying-Wei Wang Zhiru Wang 
This work was supported by grants from the National Natural Science Foundation of China(3147107,91132711,30970960);a Key Project of Shanghai Science and Technology Commission(15JC1400102,19ZR1416600).
Neuronal oscillations in the hippocampus are critical for many brain functions including learning and memory.The underlying mechanism of oscillation generation has been extensively investigated in terms of chemical sy...
关键词：Electrical synapse HIPPOCAMPUS OSCILLATION CA1 MEFLOQUINE Carbenoxolone Introduction 
Bioadhesiveness of thiolated pectin for buccal delivery of carbenoxolone sodium
《Asian Journal of Pharmaceutical Sciences》2016年第1期124-125,共2页Kamonrak Cheewatanakornkool Sathit Niratisai Pornsak Sriamornsak 
Pectin is a biopolymer that has numerous useful purposes in food and beverage industry, cosmetic products and pharmaceutical fields. One of the important properties of pectin is its bioadhesive properties. Native pect...
关键词：Thiolated PECTIN CARBENOXOLONE SODIUM BUCCAL DISC 
Structural basis for 18-β-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor被引量：5
《Acta Pharmacologica Sinica》2015年第9期1145-1150,共6页Hong ZHANG Qiang HUANG Jing ZHAI Yi-ning ZHAO Li-ping ZHANG Yun-yun CHEN Ren-weiZHANG Qing LI Xiao-peng HU 
Aim： Glyoxalase I （GLOI）, a glutathione （GSH）-dependent enzyme, is overexpressed in tumor cells and related to multi-drug resistance in chemotherapy, making GLOI inhibitors as potential anti-tumor agents. But the...
关键词：Keywords： glyoxalase 1 18-β-glycyrrhetinic acid CARBENOXOLONE pentacyclic triterpenes GSH binding site crystal structure molecular docking 
Protective effects of carbenoxolone are associated with attenuation of oxidative stress in ischemic brain injury被引量：3
《Neuroscience Bulletin》2013年第3期311-320,共10页Lang Zhang Yu-Min Li Yu-Hong Jing Shao-Yu Wang Yan-Feng Song Jie Yin 
supported by the National Natural Science Foundation of China (30872731);Natural Science Foundation of Gansu Province, China (2008GS01435 and 1010RJZA114)
Accumulating evidence has suggested that the gap junction plays an important role in the determination of cerebral ischemia, but the underlying mechanisms remain to be elucidated. In this study, we assessed the effect...
关键词：gap junction communication CEREBRALISCHEMIA reactive oxygen species 
Carbenoxolone pretreatment and treatment of posttraumatic epilepsy被引量：2
《Neural Regeneration Research》2013年第2期169-176,共8页Weiguan Chen Zhiwei Gao Yaohui Ni Zhenxiang Dai 
supported by the Social Development Program of Nantong, No. S2009035
Gap junction blocking agents can inhibit spontaneous discharge frequency in cells. We established a rat model of posttraumatic epilepsy induced using ferric ions. Rats were intraperitoneally injected with carbenoxolon...
关键词：neural regeneration brain injury posttraumatic epilepsy ferric ion gap junction CARBENOXOLONE glial fibrillary acidic protein connexin 43 SEIZURE brain injury grant-supported paper photographs-containing paper NEUROREGENERATION 
The gap junction blocker carbenoxolone enhances propofol and sevoflurane-induced loss of consciousness被引量：2
《Neural Regeneration Research》2012年第7期492-495,共4页Zhigang Liu Yongfang Liu Bo Zhao Li Du Zhongyuan Xia Xiangdong Chen Tao Luo 
supported by the Natural Science Foundation of Hubei Province, No. 2010CHB01001
General anesthetics induce loss of consciousness by inhibiting ascending arousal pathways, and they interfere with gap junction electrical coupling. The present study aimed to determine whether inhibition of gap junct...
关键词：gap junction BLOCKER PROPOFOL SEVOFLURANE general anesthesia nerve block NEUROPHARMACOLOGY 
Hypertonic stimulation induces synthesis and release of glutamate in cultured rat hypothalamic astrocytes and C6 cells被引量：1
《Neuroscience Bulletin》2008年第6期359-366,共8页曹荣 江山 段丽 熊鹰飞 高蓓 饶志仁 
supported by the National Nature Science Foundation of China(No.39770251);the Medical Foundation of the People's Liberation Army,China(No.01Z082,06MA234);the Foundation of the Fourth Military Medical University(No.05ZXJM001)
Objective To investigate whether hypertonic saline （HS） can induce the synthesis and release of glutamate in cultured hypothalamic astrocytes or C6 cell line. Methods Astrocytes were isolated, cultured, purified and...
关键词：ASTROCYTES hypertonic stimulation CARBENOXOLONE connexin 43 high performance liquid chromatography immu-nofluorescent stain RAT 
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