Carbenoxolone pretreatment and treatment of posttraumatic epilepsy  

作　　者：Weiguan Chen Zhiwei Gao Yaohui Ni Zhenxiang Dai 

机构地区：[1]Department of Rehabilitation Medicine, Affiliated Hospital of Nantong University [2]Department of Neurology, Affiliated Hospital of Nantong University

出　　处：《Neural Regeneration Research》2013年第2期169-176,共8页中国神经再生研究（英文版）

基　　金：supported by the Social Development Program of Nantong, No. S2009035

摘　　要：Gap junction blocking agents can inhibit spontaneous discharge frequency in cells. We established a rat model of posttraumatic epilepsy induced using ferric ions. Rats were intraperitoneally injected with carbenoxolone, 20 mg/kg, prior to and 30 minutes after model establishment, once a day for 14 consecutive days. Immunohistochemistry showed glial cell proliferation around a cortical focus and significantly increased connexin expression in posttraumatic epilepsy. However, carbenoxolone pretreatment or treatment significantly reduced connexin expression in the cortex, inhibited glial fibdllary acidic protein expression and ameliorated seizure degree in rats. These findings indicate that large amounts of glial cell proliferation and abnormal gap junction generation play a role in posttraumatic epilepsy, and that carbenoxolone may prevent and treat this disease.Gap junction blocking agents can inhibit spontaneous discharge frequency in cells. We established a rat model of posttraumatic epilepsy induced using ferric ions. Rats were intraperitoneally injected with carbenoxolone, 20 mg/kg, prior to and 30 minutes after model establishment, once a day for 14 consecutive days. Immunohistochemistry showed glial cell proliferation around a cortical focus and significantly increased connexin expression in posttraumatic epilepsy. However, carbenoxolone pretreatment or treatment significantly reduced connexin expression in the cortex, inhibited glial fibdllary acidic protein expression and ameliorated seizure degree in rats. These findings indicate that large amounts of glial cell proliferation and abnormal gap junction generation play a role in posttraumatic epilepsy, and that carbenoxolone may prevent and treat this disease.

关 键 词：neural regeneration brain injury posttraumatic epilepsy ferric ion gap junction CARBENOXOLONE glial fibrillary acidic protein connexin 43 SEIZURE brain injury grant-supported paper photographs-containing paper NEUROREGENERATION 

分 类 号：R742.1[医药卫生—神经病学与精神病学]