HEMICHANNEL

作品数：7被引量：7H指数：1
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相关领域：医药卫生生物学更多>>
相关作者：罗开珺刘甜朱丽萍庞尊玉更多>>
相关机构：云南大学第二军医大学中国人民解放军山东大学更多>>
相关期刊：《World Journal of Gastrointestinal Pathophysiology》《Neural Regeneration Research》《Acta Biochimica et Biophysica Sinica》《环境昆虫学报》更多>>
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Connexin therapeutics:blocking connexin hemichannel pores is distinct from blocking pannexin channels or gap junctions被引量：1
《Neural Regeneration Research》2021年第3期482-488,共7页Monica L.Acosta Mohd N.Mat Nor Cindy X.Guo Odunayo O.Mugisho Frazer P.Coutinho Ilva D.Rupenthal Colin R.Green 
supported in part by New Zealand Lottery Health Research;the Maurice and Phyllis Paykel Trust;the New Zealand Optometric Vision Research Foundation。
Compounds that block the function of connexin and pannexin protein channels have been suggested to be valuable therapeutics for a range of diseases.Some of these compounds are now in clinical trials,but for many of th...
关键词：CONNEXIN gap junction gap19 HEMICHANNEL PANNEXIN retina tonabersat 
Connexin-based signaling and drug-induced hepatotoxicity
《Journal of Clinical & Translational Research》2017年第1期45-54,共10页Michael Maes Mathieu Vinken 
Being critical mediators of liver homeostasis,connexins and their channels are frequently involved in liver toxicity.In the current paper,specific attention is paid to actions of hepatotoxic drugs on these communicati...
关键词：gap JUNCTION HEMICHANNEL CONNEXIN HEPATOTOXICITY DRUG-INDUCED liver INJURY 
Mechanical allodynia and affective behavior are improved by INI-0602,a gap junction hemichannel inhibitor,in a rat model of neuropathic pain induced by sciatic nerve injury
《中国药理学与毒理学杂志》2016年第10期1027-1028,共2页ZHANG Xiao-min FAN Li-xia PENG Yue-xia SONG Qi XIANG Yu-ke WU Wei-li WANG Qin TAO Liang 
The project supported by National Natural Science Foundation of China(81473234,U1303221)
OBJECTIVE To investigated the effects of INI-0602 on nociceptive reflex,depression-associated andanxiety-related behaviors caused by neuropathic pain in sciatic nerve injury rats.METHODS Male rat were subjected to sci...
关键词：INI-0602 gap junction hemichannel inhibitor neuropathic pain DEPRESSION ANXIETY 
斜纹夜蛾inx1,inx4基因的克隆及表达载体构建被引量：1
《环境昆虫学报》2015年第5期970-978,共9页刘信毅 罗开珺 
国家自然科学基金项目(31060251,31260448,31471823);云南省应用基础研究计划重点项目(2013FA003)
无脊椎动物innexin(inx)基因是生物进化上高度保守的基因,区别于脊椎动物的connexin。Inx基因可在细胞膜表面形成功能性的半通道蛋白hemichannel和间隙连接蛋白gap junction,这两种蛋白都与信号传导,胚胎发育,神经系统分化等功能相关。...
关键词：斜纹夜蛾 INNEXIN HEMICHANNEL 原核表达 真核表达 
Role of connexin-related signalling in hepatic homeostasis and its relevance for liver-based in vitro modelling
《World Journal of Gastrointestinal Pathophysiology》2011年第5期82-87,共6页Mathieu Vinken 
supported by grants of the FWO,the research council of the VUB and the European Union
Direct intercellular communication mediated by gap junctions constitutes a major regulatory platform in the control of hepatic homeostasis.Hepatocellular gap junctions are composed of two hemichannels of adjacent cell...
关键词：CONNEXIN HEMICHANNEL Gap junction Primary HEPATOCYTE In VITRO modelling Epigenetics HISTONE modifications Cell death Apoptosis HEPATOTOXICITY 
Emerging roles of connexin hemichannels in gastrointestinal and liver pathophysiology
《World Journal of Gastrointestinal Pathophysiology》2010年第4期115-117,共3页Mathieu Vinken Tamara Vanhaecke Vera Rogiers 
Supported partially by the Fund for Scientific Research Flanders(FWO-Vlaanderen),Belgium
Connexin hemichannels have long been considered asmere structural precursors for gap junctions.In the last decade,it has become clear that they also act as individual channels,connecting the intracellular compartment ...
关键词：HEMICHANNEL CONNEXIN PATHOPHYSIOLOGY 
Connexin 43 hemichannel regulates H9c2 cell proliferation by modulating intracellular ATP and [Ca^2＋]被引量：5
《Acta Biochimica et Biophysica Sinica》2010年第7期472-482,共11页Dongli Song Xiaoyu Liu Rujiao Liu Ling Yang Ji Zuo Wen Liu 
Connexin 43 （Cx43）, known to be the main protein building blocks of gap junctions and hemichannels in mammalian heart, plays an important role in cardiocytes proliferation. Gap junctional intercellular communication...
关键词：Wnt-3a connexin 43 H9c2 cell hernichannel PROLIFERATION 
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