Integrative analyses identified gap junction beta‐2 as a prognostic biomarker and therapeutic target for breast cancer  

作　　者：Di Zhang Lixi Li Fei Ma 

机构地区：[1]Department of Medical Oncology,Qilu Hospital of Shandong University,Jinan,China [2]Department of Medical Oncology,Qilu Hospital,Cheeloo College of Medicine,Shandong University,Jinan,China [3]Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China

出　　处：《Cancer Innovation》2024年第4期43-56,共14页肿瘤学创新（英文）

摘　　要：Background:Increasing evidence has shown that connexins are involved in the regulation of tumor development,immune escape,and drug resistance.This study investigated the gene expression patterns,prognostic values,and potential mechanisms of connexins in breast cancer.Methods:We conducted a comprehensive analysis of connexins using public gene and protein expression databases and clinical samples from our institution.Connexin mRNA expressions in breast cancer and matched normal tissues were compared,and multiomics studies were performed.Results:Gap junction beta‐2 mRNA was overexpressed in breast cancers of different pathological types and molecular subtypes,and its high expression was associated with poor prognosis.The tumor membrane of the gap junction beta‐2 mutated group was positive,and the corresponding protein was expressed.Somatic mutation and copy number variation of gap junction beta‐2 are rare in breast cancer.The gap junction beta‐2 transcription level in the p110αsubunit of the phosphoinositide 3‐kinase mutant subgroup was higher than that in the wild‐type subgroup.Gap junction beta‐2 was associated with the phosphoinositide 3‐kinase‐Akt signaling pathway,extracellular matrix–receptor interaction,focal adhesion,and proteoglycans in cancer.Furthermore,gap junction beta‐2 overexpression may be associated with phosphoinositide 3‐kinase and histone deacetylase inhibitor resistance,and its expression level correlated with infiltrating CD8+T cells,macrophages,neutrophils,and dendritic cells.Conclusions:Gap junction beta‐2 may be a promising therapeutic target for targeted therapy and immunotherapy and may be used to predict breast cancer prognosis.

关 键 词：breast cancer CONNEXIN gap junction beta‐2 phosphoinositide 3‐kinase‐Akt‐mTOR pathway prognosis 

分 类 号：R737.9[医药卫生—肿瘤]