夫妻共患变异性蕈样肉芽肿病:病毒感染和环境暴露在皮肤T细胞淋巴瘤发展中的未知作用  

Conjugal transformed mycosis fungoides: The unknown role of viral infection and environmental exposures in the development of cutaneous T-cell lymphoma

作　　者：Schmidt A.N. Robbins J.B. Greer J.P. Zic J.A. 李晓莉 

机构地区：[1]Division of Dermatology, Vanderbilt University Medical Center, Nashville, Tennessee, USA Dr.

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第8期46-46,共1页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：The etiology of mycosis fungoides (MF) is uncertain, although infectious agents and other environmental exposures have been implicated. We describe what appears to be the first case inwhich both a husband and his wife were diagnosed with large cell transformation of MF. After 10 years of having stage I MF,the wife developed tumors that showed sheets of large transformed cells with dysplastic nuclei on skin biopsies, leadingto a diagnosis of transformed MF. Her husband was diagnosed 14 months later with transformed MF following a biopsy of his right arm and leg after a 15-year history of presumed psoriasis. The fact that this rare occurrence happened in a couple who had been married for more than 25 years points to a common environmental exposure. Future studies should aim to clarify the potential role of infectious agents, such as human T-lymphotropic virus I and II, cytomegalovirus, Epstein-Barr virus, and other environmental exposures, in the development of MF.The etiology of mycosis fungoides （MF） is uncertain, although infectious agents and other environmental exposures have been implicated. We describe what appears to be the first case inwhich both a husband and his wife were diagnosed with large cell transformation of MF. After 10 years of having stage I MF, the wife developed tumors that showed sheets of large transformed ceils with dysplastic nuclei on skin biopsies, leadingto a diagnosis of transformed MF. Her husband was diagnosed 14 months later with transformed MF following a biopsy of his right arm and leg after a 15-year history of presumed psoriasis. The fact that this rare occurrence happened in a couple who had been married for more than 25 years points to a common environmental exposure. Future studies should aim to clarify the potential role of infectious agents,

关 键 词：皮肤T细胞淋巴瘤 环境暴露 肉芽肿病 异性 病毒感染 夫妻 蕈样 暴露因素 皮肤活检 病原体感染 

分 类 号：R739.5[医药卫生—肿瘤] R181.35[医药卫生—临床医学]