动脉硬化闭塞症患者股动脉粥样硬化斑块中血小板源生长因子A链的表达  

Expression of Platelet-Derived Growth Factor-A in Atherosclerosis Plaque of Arteriosclerosis Obliterans Patient

作　　者：张立燕[1] 张大伟[2] 吴学君[1] 张精勇[1] 王瑞华[1] 金星[1] 

机构地区：[1]山东省立医院血管外科,山东省济南市250021 [2]山东中医药大学附属医院周围血管科,山东省济南市250014

出　　处：《中国动脉硬化杂志》2006年第1期61-63,共3页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨血小板源生长因子A链与动脉硬化闭塞症发生的关系。方法应用免疫组织化学技术测定31例动脉硬化闭塞症患者股动脉动脉粥样硬化斑块中血小板源生长因子A链的表达。结果HE染色显示动脉硬化闭塞症患者动脉壁内膜不完整甚至缺失,平滑肌层细胞紊乱,其内有大量泡沫细胞堆积。正常人动脉壁结构完整,内膜光滑,内皮下无脂质沉积,平滑肌层细胞排列整齐。免疫组织化学检测结果发现动脉硬化闭塞症患者动脉壁动脉粥样硬化斑块内细胞胞浆中血小板源生长因子A链呈强阳性表达,而正常人动脉壁中血小板源生长因子A链仅在中膜有微量表达。结论动脉硬化闭塞症患者动脉壁动脉粥样硬化斑块中血小板源生长因子A链表达增高与动脉硬化闭塞症的发生有关。Aim To inveshgate the relationship of platelet-derived growth factor （PDGF-A） and the pathogenesis of atherosclerosis （ As）, the expression of PDGF-A in atherosclerosis （As） plaque of arteriosclerosis obliterans （ASO） patient and normal arterial wall were studied. Methods The protein level and area of PDGF-A in As plaques and normal artery of human were studied by means of immunohistochemistry. Results The arterial wall of ASO patient wasn＇t smooth, and there were very few normal endothelial ceil but a lot of foam ceil. In contrast, the normal arterial wall was very perfect, endothelial ceil and smooth muscle ceil stood on line. The data of immunohistochemistry showed that the expression of PDGF-A was augmented significantly in As plaque of ASO patient. In contrast , in noimal arterial wall the expression of PDGF-A was very low （ P〈0. 01） . Conclusions The data suggests that the increased expression of PDGF-A in As plaques of ASO related to the pathogenesis of ASO. PDGF-A play very important roles in the formation and progression of atherosclerosis.

关 键 词：病理学与病理生理学 动脉硬化闭塞症 血小板源生长因子A链 动脉粥样硬化斑块 免疫组织化学 血管平滑肌细胞 

分 类 号：R363[医药卫生—病理学]