Effect of breviscapine on fractalkine expression in chronic hypoxic rats  

作　　者：CHEN Xiao-ju CHENG De-yun YANG Li XIA Xiu-qiong GUAN Jian 

机构地区：[1]Department of Respiratory Medicine, West China Hospital,Sichuan University, Chengdu 610041, China

出　　处：《Chinese Medical Journal》2006年第17期1465-1468,共4页中华医学杂志（英文版）

基　　金：This study was supported by a research grant from the National Natural Science Foundation of China(No.30370629).

摘　　要：Fractalkine （FKN） is the only known chemokine that fulfils the dual functions of an adhesive molecule and a soluble chemoattractant.1 FKN expression was reported increase in lungs of patients with severe pulmonary arterial hypertension,2 suggesting that FKN may participate in pathogenesis of pulmonary hypertension. Breviscapine is a flavonoid extracted from Erigeron breviscapus （Vant.） Hand. Mazz. Breviscapine can prevent the development of hypoxic pulmonary hypertension^3 but the mechanism is unknown. This study evaluated the role of FKN in the pathogenesis of hypoxic pulmonary hypertension and the effect of breviscapine on FKN in hypoxic pulmonary hypertension.Fractalkine （FKN） is the only known chemokine that fulfils the dual functions of an adhesive molecule and a soluble chemoattractant.1 FKN expression was reported increase in lungs of patients with severe pulmonary arterial hypertension,2 suggesting that FKN may participate in pathogenesis of pulmonary hypertension. Breviscapine is a flavonoid extracted from Erigeron breviscapus （Vant.） Hand. Mazz. Breviscapine can prevent the development of hypoxic pulmonary hypertension^3 but the mechanism is unknown. This study evaluated the role of FKN in the pathogenesis of hypoxic pulmonary hypertension and the effect of breviscapine on FKN in hypoxic pulmonary hypertension.

关 键 词：HYPOXIA pulmonary hypertension FRACTALKINE BREVISCAPINE 

分 类 号：R563[医药卫生—呼吸系统]