老年短暂性脑缺血发作与脂蛋白(a)和D-二聚体的关系  

Relationship between the levels of serum lipoprotein (a) and plasma D-dimer and transient ischemic attack in aged people

作　　者：杨艳敏[1] 李慎贤[2] 毕国荣[3] 彭扬[1] 李慧[1] 何平[1] 

机构地区：[1]中国医科大学附属第二医院老年科,辽宁沈阳110004 [2]中国医科大学附属第二医院中医科,辽宁沈阳110004 [3]中国医科大学附属第二医院神经内科,辽宁沈阳110004

出　　处：《中国医科大学学报》2006年第3期286-287,共2页Journal of China Medical University

基　　金：辽宁省自然科学基金资助项目(20032058)

摘　　要：目的探讨老年短暂性脑缺血发作(TIA)与血清脂蛋白(a)[Lp(a)]和血浆D-二聚体的关系。方法92例老年TIA患者按病程划分为A、B、C3组,所有病例在起病24h内检测血清Lp(a)和D-二聚体的含量,观察72h内头CT或MRI后与正常对照组进行比较。结果老年TIA患者血清Lp(a)和D-二聚体的含量明显高于正常对照组(P<0.01),B、C组Lp(a)和D-二聚体的含量均高于A组(P<0.01),而且C组高于B组(P<0.05),重型TIA患者明显高于轻、中型患者。TIA各组Lp(a)与D-二聚体含量均呈显著正相关,P均<0.01。结论Lp(a)和D-二聚体含量的升高可以对老年TIA患者的诊断、治疗和估计预后提供较可靠的实验室指标。Objeetive： To investigate the relationship between the levels of serum lipoprotein （a） and plasma D-dimer and transient ischemic attack （TIA） in aged people. Methods： Ninety-two aged patients with TIA were divided into 3 groups： group A （TIA persisted ≤ 60 minutes and then relieved）, group B （TIA persisted 〉 60 minutes and repeated）, and group C （TIA developed into cerebral infarction 24 hours after the onset of TIA）. The levels of serum lipoprotein （a） and plasma D-dimer were detected within 24 hours of TIA onset. Head CT or MRI was carried out within 72 hours of TIA onset. Results： The levels of serum lipoprotein （a） and plasma D-dimer in aged patients with TIA were significantly higher than those in normal controls （ P 〈 0.01 ）. The levels of serum lipoprotein （a） and plasma D-dimer in group B and C were higher than those in group A （ P 〈 0.01 ）, and in group C the levels were higher than those in group B （ P 〈0.05）. The plasma D-dimer level positively related to serum lipoprotein （a） level in TIA patients. Conclusion： The increase of the levels of serum lipoprotein （a） and plasma D-dimer may provide reliable evidence for the diagnosis, treatment, and prognosis of TIA in aged people.

关 键 词：短暂性脑缺血发作 脂蛋白(a) D-二聚体 

分 类 号：R743.31[医药卫生—神经病学与精神病学]