青少年鼻咽癌放疗效果与预后因素分析  

Analysis of radiotherapy results and prognostic factors of the adolescence with nasopharyngeal carcinoma

作　　者：陈洪雷[1] 张苗[1] 肖作平[2] 彭勇[1] 

机构地区：[1]解放军第88医院,山东泰安271000 [2]第二军医大学附属长海医院,上海200433

出　　处：《泰山医学院学报》2006年第3期260-262,共3页Journal of Taishan Medical College

摘　　要：目的回顾性分析49例青少年鼻咽癌患者的放疗效果及影响预后的因素。方法1990年1月至1997年12月共收治30岁以下的鼻咽癌患者49例,其中男31例,女18例,年龄5～30岁(平均23．2岁)。全部病例均予常规外照射,原发灶及颈部转移淋巴结区剂量44-70 Cy/5～8周,颈部预防剂量30～44 Gy/3～5周。结果平均随访84个月(14～152个月),总5年生存率为59．2%。T_(1-2)与T_(3-4)者的5年生存率分别为74．1%和40．9%(P＜0．025),N_(0-1)与N_(2-3)者的5年生存率分别为81．3%和48．5%(P＜0．05),均有显著性差异。结论青少年鼻咽癌放疗效果较好,T和N分期是影响预后的主要因素。Objective： To analyze the radiotherapy results and prognostic factors of the adolescent with nasopharyngeal carcinoma （NPC） retrospectively. Methods： From Jan 1990 to Dec 1997, 49 patients under 30 years old with NPC were treated in our department, which included 31 males and 18 females with the median age of 23.2 （ range between 5 and 30 ） years. All patients were treated with conventional radiotherapy. Total dose delivered to the primary tumor and metastatic cervical lymph nodes was 44 - 70 Gy in 5 - 8 weeks. The dose of normal neck area was 30 - 44 Gy in 3 - 5 weeks. Results： With a median follow-up of 84 （ 14 - 152） months, the overall 5-year survival rate was 59. 2%. The 5-year survival rates of patients with T1-2 and T3-4were 74. 1% and 40. 9% （ P 〈0. 025 ）. The 5-year survival rates of patients with N0-1 and N2-3 were 81.3% and 48.5% （ P 〈 0. 05 ）. Conclusion： The radiotherapy can achieve good results in adolescent NPC patients. T and N Stage are important prognostic factors.

关 键 词：鼻咽肿瘤 放射疗法 预后 青少年 

分 类 号：R739.63[医药卫生—肿瘤]