Muscle fatigue in women with primary biliary cirrhosis:Spectral analysis of surface electromyography  

作　　者：Maria Rosa Biagini Alessandro Tozzi Antonello Grippo Andrea Galli Stefano Milani Aldo Amantini 

机构地区：[1]Department of Clinical Pathophysiology Gastroenterology Unit,University of Florence,AOU Careggi,Firenze,Italy [2]Department of Neurological Science Neurophysiological Unit,University of Florence,AOU Careggi,Firenze,Italy

出　　处：《World Journal of Gastroenterology》2006年第32期5186-5190,共5页世界胃肠病学杂志（英文版）

摘　　要：AIM： To evaluate the myoelectric manifestations of peripheral fatigability in patients with primary biliary cirrhosis in comparison to healthy subjects. METHODS： Sixteen women with primary biliary cirrhosis without comorbidity and 13 healthy women matched for age and body mass index （BMI） completed the selfreported questionnaire fatigue impact scale. All subjects underwent surface electromyography assessment of peripheral fatigability. Anterior tibial muscle isometric voluntary contraction was executed for 20 s at 80% of maximal voluntary isometric contraction. During the exercise electromyographic signal series were recorded and root mean square （expression of central drive） as well as mean and median of electromyographic signal frequency spectrum （estimates of muscle fatigability） were com- puted. Each subject executed the trial two times. EMG parameters were normalized, then linear regression was applied and slopes were calculated. RESULTS： Seven patients were fatigued （median fatigue impact scale score： 38, range： 26-66） and 9 were not fatigued （median fatigue impact scale score： 7, range： 0-17）. The maximal voluntary isometric contraction was similar in patients （82, 54-115 N） and controls （87, 74-101 N）, and in patients with high （81, 54-115 N） and low fatigue impact scale scores （86, 65-106 N）. Root mean square as well as mean and median of frequency spectrum slopes were compared with the Mann-Whitney U test, and no significant difference was found between fatigued and non-fatigued patients and controls. CONCLUSION： No instrumental evidence of peripheral fatigability can be found in women with primary biliary cirrhosis but no comorbidity, suggesting that fatigue in such patients may be of central origin.瞄准：与健康题目相比与主要胆汁性肝硬变在病人评估外部易疲性的肌电表明。方法：有没有 comorbidity 的主要胆汁性肝硬变的十六个女人和好久匹配的 13 个健康女人和身体团索引(BMI ) 完成了自我报导的问询表疲劳影响规模。所有题目经历了对外部易疲性的表面肌电描记法评价。前面的胫骨的肌肉等轴的随意收缩在 80% 最大的自愿的等长收缩为 20 s 被执行。在锻练 electromyographic 信号期间，系列象 electromyographic 信号频率光谱(肌肉易疲性的估计) 的平均数和 median 一样被记录，根意味着平方(中央开车的表达式) 被计算。每个题目执行了试用 two times。EMG 参数被规范的、然后线性的回归被使用，斜坡是计算的。结果：七个病人被使疲劳(中部的疲劳影响规模分数：38，变化：26-66 ) 并且 9 没被使疲劳(中部的疲劳影响规模分数：7，变化：0-17 ) 。最大的自愿的等长收缩在病人是类似的(82， 54-115 N ) 并且控制(87， 74-101 N ) ，并且在有高度的病人(81， 54-115 N ) 并且低疲劳影响规模分数(86， 65-106 N ) 。方形以及频率光谱斜坡吝啬、中部的根平均数与 Mann-Whitney U 测试相比，并且没有有效差量被发现在之间使疲劳并且非使 \O 疲劳的病人和控制。结论：外部易疲性的仪器的证据都不能与主要胆汁性肝硬变而是没有 comorbidity 在女人被发现，建议在如此的病人的那疲劳可能具有中央起源。

关 键 词：Primary biliary cirrhosis CHOLESTASIS Surfaceelectromyography Peripheral fatigue Muscle fatigue FATIGABILITY Root mean square Mean frequency Medianfrequency Fatigue impact scale 

分 类 号：R575.2[医药卫生—消化系统]