5羟色胺1A(5-HT_(1A))受体参与调制大鼠丘脑中央下核5-HT诱发的抗伤害感受效应  

5-Hydroxytryptamine 1A (5-HT_(1A)) receptor is involved in mediating the nucleus submedius 5-HT-evoked antinociception in rats

作　　者：肖丹秦[1] 朱娟霞[1] 贾红[2] 唐敬师[2] 

机构地区：[1]西安医学院生理教研室,西安710068 [2]西安交通大学医学院生理教研室

出　　处：《陕西医学杂志》2006年第9期1073-1076,共4页Shaanxi Medical Journal

基　　金：国家自然科学基金项目(No30270453)

摘　　要：目的:研究5-HT1A受体是否参与调节中虫下核(Sm)内由5-HT引起的抗伤害效应。方法:以辐射热诱发浅麻大鼠甩尾(TF)反射潜伏期为痛反应指标,在Sm内单独微量注射5-HT1A受体拮抗剂。结果:5-HT1A受体拮抗剂p-MPPI(0.87nmol)可易化TF反射,小剂量的p-MPPI(0.43nmol)可明显减弱Sm内注射5-HT后引起的甩尾(TF)反射抑制效应。结论:5-HT1A受体参与调制大鼠丘脑中央下核5-HT诱发的抗伤害感受效应。Objective ; To examine whether the 5-HTIA receptors are involved in the Sm 5-HT- evoked antinociception, Methods： Nociception was assessed in lightly anesthetized rats with radiant -beatevoked tail flick （TF）. 5-HT1A receptor antagonist was microinjected into the Sm alone or in combination with a microinjection of 5-HT into the same Sm site. Results： 5-HT1A receptor antagonist p-MPPI （0.87 nmol） facilitated the TF reflex; a lower dose （0. 43 nmol） of p-MPPI significantly attenuated the Sm 5- HT- evoked inhibition of TF reflex. Conclusion： 5-HT1A receptor is involved in mediating the 5-HT- evoked antinociception,

关 键 词：丘脑后核/病理生理学 丘脑后核/药物作用 受体 血清素 血清素/治疗 应用 大鼠 

分 类 号：R749.4[医药卫生—神经病学与精神病学]