杂色曲霉素体外对人胃粘膜的致癌作用  

The Sterigmatocystin Carcinogenesis in Cultured Human Gasttric Mucosae

作　　者：谢同欣[1] 张祥宏[1] 严霞[1] 王凤荣[1] 

机构地区：[1]河北医学院基础所病理室

出　　处：《肿瘤防治研究》1996年第6期341-343,共3页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金

摘　　要：河北省赞皇县是胃癌高发区，我们以往的研究表明该地区胃癌高发与杂色曲霉毒素密切相关。为进一步探讨杂色曲霉毒素对人胃粘膜的致癌作用，于本研究中，用该毒素处理体外培养的人胎儿胃粘膜。处理后１８天，经流式细胞分析显示胃粘膜组织Ｓ期、Ｇ２Ｍ期细胞数和细胞增殖指数增大；接种于；γ－射线处理的新生ＳＤ大鼠皮下可存活生长，形态学是重度不典型增生。结果表明杂色曲霉毒素对人胃粘膜有致癌作用。Zanhuang county of Hebei Province in China is a high risk area of stomach cancer. Our previous studies showed that the carcinog enesis of stomach in this area was closely associated with sterigmatocystin(ST). In the present study, cultured human felal gastric mucosae were treated with ST and 18 days latey, the gastric mucosae were analyzed with flow cytometer and subcutaneously inoculated into the r-ray irradiated SD newborn rats respectively. The results indicated that the cell numbers in S and G2M phases in cell cycle and Proliferation index from the STtreated mucosae increased dramatically compared with that from mucosae in contral group, and the mucosae in the ST-treated explants inoculated into the rats appeared morphologically severe atypical hyperplasia changes, in contrast, the inoculated explants in the control group disappeared completely. These results suggest showed that ST may be a carcinogen for human gastric mucosae.

关 键 词：杂色曲霉素 胃粘膜 胃肿瘤 致癌性 病因 

分 类 号：R735.202[医药卫生—肿瘤]