密闭环境3－甲基吲哚最高容许浓度的实验研究  

A Study on Maximum Allowable Concentration of 3 methylindole in Closed Environment.

作　　者：余秉良[1,2,1,2] 张恒泰[1,2] 于芳[1,2] 曾昭慧 徐增军 吕伯钦[1,2] 余秉良 

机构地区：[1]航天医学工程研究所 [2]中国预防医学科学院劳动卫生职业病研究所

出　　处：《航天医学与医学工程》1996年第6期426-430,共5页Space Medicine & Medical Engineering

摘　　要：为制定密闭环境空气３甲基吲哚（３ＭＩ）的最高容许浓度，进行了人体气味试验，并采用肺组织过氧化物丙二醛、脾细胞数和脾重量等指标，对雄性大鼠进行了急性和亚急性毒性参数的测定。结果为大鼠口服半数致死量为１８３０ｍｇ／ｋｇ，急性阈剂量小于１８３ｍｇ／ｋｇ，亚急性阈剂量为６１ｍｇ／ｋｇ，人体厌恶阈为０．７５ｍｇ／ｍ３。根据上述结果，结合密闭环境暴露特点和要求，论证外推密闭环境３ＭＩ的短期暴露最高容许浓度为０．５ｍｇ／ｍ３。methylindole is a normal metabolic product of humans. It has a foul odor and is toxic to the lung and spleen.In order to determine maximum allowable concentration of 3 methylindole in closed environment,acute and subacute toxic effects in male rats were studied by detecting malondialdehyde in lung tissue,spleen cell counts and spleen weight.It is suggested that the oral median lethal dose(LD 50 ),the acute and subacute toxic thresholds in rats are 1830mg/kg,<183mg/kg and 61mg/kg,respectively, and the nuisance threshold for men is 0.75mg/m 3.The recommended occupational exposure limit may be set at 46mg/m 3. According to the features of exposure in closed environment and essential requirements,the extrapolated maximum allowable concentration of 3 methylindole in closed environment may be set at 0.5mg/m 3.

关 键 词：甲基吲哚 密闭舱 气味 最高允许浓度 空气污染 

分 类 号：R852.14[医药卫生—航空、航天与航海医学]