β─胡萝卜素对促癌剂抑制细胞间隙连接通讯的影响  

Effects of β carotene on the inhibition of gap junctional intercellular communication by tumor promoter

作　　者：朱俊东[1] 陈东升[1] 糜漫天[1] 杨家驹[1] 石元刚[1] 

机构地区：[1]第三军医大学预防医学系营养与食品卫生学教研室

出　　处：《第三军医大学学报》1996年第4期324-326,共3页Journal of Third Military Medical University

基　　金：国家自然科学基金

摘　　要：研究了β－胡萝卜素（β－ｃａｒｏｔｅｎｅ）在ＳｗｉｓｓＮＩＨ／３Ｔ３细胞中的代谢情况及其对促癌剂ＴＰＡ（１２－ｏ－ｔｅｔｒａｄｅｃａｎｏｙｌ－１３－ｐｈｏｒｂｏｌ－ａｃｅｔａｔｅ）抑制ＮＩＨ／３Ｔ３细胞间隙连接通讯（ＧＪＩＣ）的影响。结果显示：β－胡萝卜素在ＮＩＨ／３Ｔ３细胞中不能转化为视黄醇，对ＮＩＨ／３Ｔ３细胞ＧＪＩＣ功能有诱导作用，同时对ＴＰＡ抑制ＮＩＨ／３Ｔ３细胞ＧＪＩＣ功能有不同程度的拮抗作用。提示β－胡萝卜素的抗癌作用可能与细胞ＧＪＩＣ功能变化有关。The metabolism of β carotene and its effects on the inhibition of gap junctional intercellular communication (GJIC) by the tumor promoter 12 O tetradecanoyl 13 phorbol acetate (TPA) in Swiss NTH/3T3 cells were determined. It was found that β carotene enhanced GJIC among the normal NTH/3T3 cells in a dose dependent manner and exerted antagonizing effects to various degrees on the inhibition of GJIC by TPA but it could not be converted to retinol in these cells. Our findings suggest that the anticarcinogenic effects of β carotene might be correlated to the functional changes of GJIC.

关 键 词：Β-胡萝卜素 促癌剂 细胞间隙 连接通讯 

分 类 号：R730.5[医药卫生—肿瘤]