乳酸生产中的微生物代谢工程  

Microrganism Metabolic Engineering in Lactic Acid Production

作　　者：王海燕[1] 刘铭[2] 王化军[1] 曹竹安[2] 

机构地区：[1]北京科技大学环境工程系,北京100083 [2]清华大学化学工程系,北京100084

出　　处：《过程工程学报》2006年第3期512-516,共5页The Chinese Journal of Process Engineering

基　　金：国家重点基础研究发展计划(973)资助项目(编号:2003CB716007)

摘　　要：从代谢工程的角度综述了同型及异型乳酸发酵的代谢途径、乳酸菌代谢模型、乳酸脱氢酶在乳酸生产方面的应用、米根霉发酵生产乳酸的代谢工程和基因工程阻断乙醇代谢途径改造乳酸的生产过程等方面的研究进展,讨论了生物信息学及环境胁迫对乳酸代谢的影响,展望了乳酸的微生物代谢工程的发展趋势.Metabolic engineering can regulate the metabolic networks of the microbial cells. It plays an important role in selecting microorganisms and optimizing the process to enhance metabolites production. The progress of the metabolic engineering research in lactic acid production was reviewed. Metabolic pathways in homo-fermentation and hetero-fermentation for lactic acid production were compared. The metabolic model of lactic acid bacteria, the application of lactate dehydrogenase and the production of lactic acid with Rhizopus oryzae fermentation were summarized. The gene regulatory knockout of ethanol metabolic pathway for improving the lactic acid production was introduced. The influences of bioinformatics and stress response on the metabolism of lactic acid were discussed. And the trends in microbial production of lactic acid were also predicted.

关 键 词：乳酸 微生物生产 代谢工程 

分 类 号：Q93[生物学—微生物学]