Erythropoietin and cerebral vascular protection:role of nitric oxide  

作　　者：Anantha VijayRSANTHANAM Zvonimir SKATUSIC 

机构地区：[1]Departments of Anesthesiology and Molecular Pharmacology and Experimental Therapeutics,Mayo Clinic College of Medicine,Rochester,Minnesota 55905,USA

出　　处：《Acta Pharmacologica Sinica》2006年第11期1389-1394,共6页中国药理学报（英文版）

摘　　要：Cerebral vasospasm after subarachnoid hemorrhage （SAH） is a major clinical problem causing cerebral ischemia and infarction. The pathogenesis of vasospasm is related to a number of pathological processes including endothelial damage and alterations in vasomotor function leading to narrowing of arterial diameter and a subsequent decrease in cerebral blood flow. Discovery of the tissue protective effects of erythropoietin （EPO） stimulated the search for therapeutic application of EPO for the prevention and treatment of cerebrovascular disease. Recent studies have identified the role of EPO in vascular protection mediated by the preservation of endothelial cell integrity and stimulation of angiogenesis. In this review, we discuss the EPO-induced activation of endothelial nitric oxide （NO） synthase and its contribution to the prevention of cerebral vasospasm.Cerebral vasospasm after subarachnoid hemorrhage （SAH） is a major clinical problem causing cerebral ischemia and infarction. The pathogenesis of vasospasm is related to a number of pathological processes including endothelial damage and alterations in vasomotor function leading to narrowing of arterial diameter and a subsequent decrease in cerebral blood flow. Discovery of the tissue protective effects of erythropoietin （EPO） stimulated the search for therapeutic application of EPO for the prevention and treatment of cerebrovascular disease. Recent studies have identified the role of EPO in vascular protection mediated by the preservation of endothelial cell integrity and stimulation of angiogenesis. In this review, we discuss the EPO-induced activation of endothelial nitric oxide （NO） synthase and its contribution to the prevention of cerebral vasospasm.

关 键 词：cerebral vasospasm tissue protection nitricoxide synthase ENDOTHELIUM 

分 类 号：R743[医药卫生—神经病学与精神病学]