fascin蛋白在结、直肠腺瘤和癌中的表达及意义  

Significance of fascin expression in colorectal adenoma and carcinoma

作　　者：杨强[1] 卢朝辉[2] 罗玉凤[2] 万建伟[2] 曹金伶[2] 高洁[2] 武莎菲[2] 陈杰[2] 

机构地区：[1]中日友好医院病理科 [2]中国医学科学院中国协和医科大学北京协和医院病理科,北京100730

出　　处：《诊断病理学杂志》2006年第5期359-361,I0012,共4页Chinese Journal of Diagnostic Pathology

基　　金：国家自然科学基金(30471970);罗氏科研基金资助

摘　　要：目的探讨fascin蛋白在结、直肠腺瘤和癌中的表达及其临床病理意义。方法用免疫组化方法检测41例结、直肠癌,38例腺瘤及20例正常上皮中fascin蛋白的表达。肿瘤细胞染色>5%的病例定为阳性。结果41例结、直肠癌中有17例(41·5%)表达,而且fascin蛋白的表达和浆膜侵犯(P=0·005)、肿瘤分级(P=0·002)、TNM分期(P=0·011)、淋巴结转移(P=0·011)、p53表达(P=0·047)及Ki-67表达(P=0·034)等因素相关,与年龄、性别、组织学类型无关。27例中、重度异型增生腺瘤中仅3例(11·1%)表达,11例轻度异型增生腺瘤及正常上皮均不表达。结论在结、直肠癌的多步发生过程中,fascin蛋白表达看来是一迟发事件,通常在癌中表达,并与肿瘤侵袭和转移相关,有可能成为新的治疗靶点。Objective To investigate the significance of fascin protein expression in colorectal adenoma and carcinoma. Methods 41 cases of colorectal carcinoma, 38 cases of colorectal adenoma and 20 cases of normal tissues were y investigated using monoclonal antifascin antibody. Staining more than 5 % of turnor cells was recorded as positive immunoreactivity. Results Overall, fascin immunoreactivity was detected in 17 out of 41 cases of colorectal carcinoma （41.5%）, and fascin expression was correlated with serosal invasion （ P = 0.005）, histopathological grading （ P = 0.002）, TNM stage （ P = 0.011 ）, positive lymph node metastasis （ P = 0.011 ）, P53 expression （ P = 0.047） and Ki-67 expression （ P = 0.034）, but not correlated with age （ P = 0.412）, gender（ P = 0.326） and histological classification （ P = 0.540）. fascin expression was only seen in 3 out of 27 cases of intermediate and high grade dysplastic adenoma （ 11.1% ）, and not in 11 cases of low grade dysplastic adenoma and normal tissues. Conclusions： In the multistep pathogenesis of colorectal carcinoma, fascin expression seems to be a late event, usually present in carcinoma, and correlated with invasion and metastasis of carcinoma. Targetting the fascin pathway could be a novel therapeutic strategy of colorectal carcinoma.

关 键 词：FASCIN 结、直肠肿瘤 免疫组化 

分 类 号：R735.3[医药卫生—肿瘤]