Clinical Report on Californium-252 Neutron Intraluminal Brachytherapy Combined with External Irradiation for Cervical Carcinoma Treatment  

作　　者：Huanyu Zhao Keming Wang Jian Sun Xin Geng Weiming Zhang 

机构地区：[1]Tianjin Medical University, Tianjin 300070, China. [2]The Second Affiliated Hospital of Nanjing Medical University, Nanjing210011, China.

出　　处：《Chinese Journal of Clinical Oncology》2006年第5期337-342,共6页中国肿瘤临床（英文版）

摘　　要：OBJECTIVE To observe the curative effects and complications of californium-252 （^252Cf） neutron intraluminal brachytherapy （IBT） combined with external irradiation （El） for treatment of cervical carcinoma.METHODS From December 2000 to December 2004, 128 cases of cer vical carcinoma staged into IIA-IIIB according to the International Federation of Gynecology and Obstetrics （FIGO） standards were treated with ^252Cf neutron IBT using 8-10 Gy per fraction, once a week. The total dose at reference A point was 36-40 Gy in 4-5 fractions. From the second day after ^252Cf neutron IBT treatment, the whole pelvic cavity was treated with ^60Co y-ray El, applying 2 Gy per fraction, 4 times per week. After 20-25Gy of El, the center of the whole pelvic field was blocked with 4 cm of lead in width. The total dose of El was 45-50 Gy.RESULTS The short-term therapeutic effects were CR 95.3% and PR 4.7%. The 3 and 5-year local control rates were 93.5% and 87.9%. The overall 3-year survival rate was 87.5% and for Stages Ⅱ and Ⅲ , 90.9% and 81.5% respectively; the overall 5-year survival rate was 70% and for Stages II and III, 76.2% and 61% respectively. The rate of radiation complications was 4.7% for radiation cystitis, 7.8% for radiation proctitis, 6.3% for vagina contracture and adhesion and 5.5% for protracted radiation proctitis.CONCLUSION An combination of ^252Cf neutron IBT with El for treatment of cervical carcinoma can be well-tolerated by cervical carcinoma patients. The rate of local tumor control is high and radiation complications are few.OBJECTIVE To observe the curative effects and complications of californium-252 (252Cf) neutron intraluminal brachytherapy (IBT) combined with external irradiation (El) for treatment of cervical carcinoma. METHODS From December 2000 to December 2004, 128 cases of cervical carcinoma staged intoⅡA-ⅢB according to the International Federation of Gynecology and Obstetrics (FIGO) standards were treated with 2S2Cf neutron IBT using 8-10 Gy per fraction, once a week. The total dose at reference A point was 36-40 Gy in 4-5 fractions. From the second day after 252Cf neutron IBT treatment, the whole pelvic cavity was treated with 60Coγ-ray El, applying 2 Gy per fraction, 4 times per week. After 20-25 Gy of El, the center of the whole pelvic field was blocked with 4 cm of lead in width. The total dose of El was 45-50 Gy. RESULTS The short-term therapeutic effects were CR 95.3% and PR 4.7%. The 3 and 5-year local control rates were 93.5% and 87.9%. The overall 3-year survival rate was 87.5% and for StagesⅡandⅢ, 90.9% and 81.5% respectively; the overall 5-year survival rate was 70% and for StagesⅡandⅢ, 76.2% and 61% respectively. The rate of radiation complications was 4.7% for radiation cystitis, 7.8% for radiation proctitis, 6.3% for vagina contracture and adhesion and 5.5% for protracted radiation proctitis. CONCLUSION An combination of 252Cf neutron IBT with El for treatment of cervical carcinoma can be well -tolerated by cervical carcinoma patients. The rate of local tumor control is high and radiation complications are few.

关 键 词：califomium-252 neutron BRACHYTHERAPY RADIOTHERAPY cervical carcinoma. 

分 类 号：R737.33[医药卫生—肿瘤]