Microsurgical treatment of craniopharyngiomas:report of 284 patients  

作　　者：SHI Xiang-en WU Bin ZHOU Zhong-qing FAN Tao ZHANG Yong-li 

机构地区：[1]Department of Neurosurgery, Brain Science Institute of Beijing, Fuxing Hopital, Capital Medical University, Beijing 100038, China

出　　处：《Chinese Medical Journal》2006年第19期1653-1663,共11页中华医学杂志（英文版）

摘　　要：Background Generally, total surgical removal of craniopharyngioma results in satisfactory outcome with a low recurrence rate, however, the location of the tumor and its adherence to the hypothalamic structures can make the operation difficult. The goal of the present study was to assess the outcome of craniopharyngiomas in 284 patients treated surgically. Methods A total of 284 patients （151 men and 133 women） with craniopharyngioma were treated surgically by our neurosurgeons from January 1996 to March 2006. Among them, 226 （79.6%） patients were adults （15 years of age or older; mean, 35.8 ± 10.6）, 58 （20.4%） were children （14 years of age or younger; mean, 9.1 ± 3.8）. The diameter of the tumors were 2.0-9.0 cm （mean, 36.54± 11.4）. The tumors were classified into the superior （23 patients） and inferior ventricular （261） types according to the location of the tumor relative to the third ventricular floor. For the patients with craniopharyngioma of inferior ventricular type, pterional approach was used in 191 （67.3%） patients, subfrontal approach in 17 （6.0%）, and translamina terminalis through frontobasal interhemispheric approach in 53 08.7%）. For those with the tumors of superior ventricular type, transcallosal approach into the anterior third ventricle was done in 10 （3.5%） patients, and the lamina terminalis approach in 13 （4.6%）. Of the 284 patients, 204 （71.8%） were followed up for 0.5 to 8 years （mean, 2.1 ± 1.8）, including 162 patients received total tumor removal, and 37 underwent subtotal or partial removal. Results Total, subtotal and partial removal of the tumors were achieved in 237 （83.5%）, 34 （12.0%） and 13 （4.5%） patients, respectively. The pituitary stalk was preserved in 176 （62.0%） patients, severed in 52 （18.3%）, and unidentified in 56 （19.7%）. Twelve （4.2%） patients died within one month after the surgery. During the follow-up, 23 （14.1%） patients experienced tumor recurrence 1.0-3.5 years （mean, 1Background Generally, total surgical removal of craniopharyngioma results in satisfactory outcome with a low recurrence rate, however, the location of the tumor and its adherence to the hypothalamic structures can make the operation difficult. The goal of the present study was to assess the outcome of craniopharyngiomas in 284 patients treated surgically. Methods A total of 284 patients （151 men and 133 women） with craniopharyngioma were treated surgically by our neurosurgeons from January 1996 to March 2006. Among them, 226 （79.6%） patients were adults （15 years of age or older; mean, 35.8 ± 10.6）, 58 （20.4%） were children （14 years of age or younger; mean, 9.1 ± 3.8）. The diameter of the tumors were 2.0-9.0 cm （mean, 36.54± 11.4）. The tumors were classified into the superior （23 patients） and inferior ventricular （261） types according to the location of the tumor relative to the third ventricular floor. For the patients with craniopharyngioma of inferior ventricular type, pterional approach was used in 191 （67.3%） patients, subfrontal approach in 17 （6.0%）, and translamina terminalis through frontobasal interhemispheric approach in 53 08.7%）. For those with the tumors of superior ventricular type, transcallosal approach into the anterior third ventricle was done in 10 （3.5%） patients, and the lamina terminalis approach in 13 （4.6%）. Of the 284 patients, 204 （71.8%） were followed up for 0.5 to 8 years （mean, 2.1 ± 1.8）, including 162 patients received total tumor removal, and 37 underwent subtotal or partial removal. Results Total, subtotal and partial removal of the tumors were achieved in 237 （83.5%）, 34 （12.0%） and 13 （4.5%） patients, respectively. The pituitary stalk was preserved in 176 （62.0%） patients, severed in 52 （18.3%）, and unidentified in 56 （19.7%）. Twelve （4.2%） patients died within one month after the surgery. During the follow-up, 23 （14.1%） patients experienced tumor recurrence 1.0-3.5 years （mean, 1

关 键 词：CRANIOPHARYNGIOMA MICROSURGERY TREATMENT 

分 类 号：R739.63[医药卫生—肿瘤]