COX-2、VEGF、cyclin D1在胃癌及慢性萎缩性胃炎的表达及其意义  

Expression and its of COX-2,VEGF and cyclin D1 in gastric carcinoma and chronice atrophic gastritis and its significance

作　　者：武春燕[1] 胡怀远[1] 马国栋[1] 刘岩[1] 

机构地区：[1]皖北矿务局总医院病理科,安徽宿州234000

出　　处：《蚌埠医学院学报》2006年第6期622-623,共2页Journal of Bengbu Medical College

基　　金：安徽省淮北市科技局资助项目(05184)

摘　　要：目的：探讨COX-2、VEGF、cyclinD1蛋白在胃癌及慢性萎缩性胃炎组织中的表达及其意义。方法：采用免疫组化法检测COX-2、VEGF、cyclin D1蛋白在60例胃癌组织和20例慢性萎缩性胃炎组织中的表达。结果：COX-2、VEGF、cyclin D1在胃癌和慢性萎缩性胃炎组织中的阳性表达率分别为66．67％、76．67％、61．67％和40．00％、35．00％、15．00％，差异均有统计学意义（P〈0．005，P〈0．05）。结论：cox-2、VEGF、cyclinD1蛋白的阳性表达与慢性萎缩性胃炎癌变有一定关系。Objective：To investigate the expression of cyclooxyenase-2（COX-2） ,vascular endothelial cell growth factor（VEGF） and cyclin D1 in gastric carcinoma and chronice atrophic gastritis and its significance. Methods：The expression of COX-2, VEGF and cyclin D1 in 60 cases of gastric carcinoma and 20 cases of Chronic atrophic gastritis was studied by immunohistochemical method. Results ：The positive rate of COX-2 was 66.67% in gastric carcinoma , which was higher than that in chronic atrophic gastritis （ P 〈 0.05 ）. The positive rate of VEGF was76.67% in gastric carcinoma, which was higher than that in chronic atrophic gastritis （ P 〈 0. 005）. The positive rate of cyclin D1 was 61.67% in gastric carcinoma,which was significantly higher than that in chronic atrophic gastritis（P 〈 0. 005 ）. Conclusions：The expression level of COX-2, VEGF and cyclin D1 may be closely correlated with the cancerous transformation process of chronic atrophic gastritis.

关 键 词：胃肿瘤 腺癌 胃炎 萎缩性 免疫组织化学 COX-2 VEGF CYCLIN D1 

分 类 号：R735.2[医药卫生—肿瘤]