健脾益气对神经内分泌免疫网络影响的实验研究  

Experimental researches on the effect of strenthening the spleen and replenishing Qi on neuroendocine immune network

作　　者：陈晓红[1] 蔡定芳[1] 沈自尹[1] 张玲娟 钟历勇 

机构地区：[1]上海医科大学华山医院

出　　处：《中国中医基础医学杂志》1996年第5期26-29,共4页JOURNAL OF BASIC CHINESE MEDICINE

摘　　要：为了观察健脾益气对神经内分泌免疫网络的调节作用，本实验用皮质酮（１０ｍｇ／ｋｇ）造成大鼠下丘脑—垂体—肾上腺—胸腺（ＨＰＡＴ）轴抑制模型，观察健脾益气代表名方四君子汤（ＳＪ）对ＨＰＡＴ轴的影响。结果表明皮质酮大鼠下丘脑单胺类递质的含量明显增高，血浆ＡＣＴＨ、ＣＯＲＴ含量明显降低，体内与体外淋巴细胞增殖反应明显受抑，自然杀伤细胞活性下降，淋巴细胞诱生的ＩＬ—２和γ—ＩＦＮ水平明显降低。２００％四君子汤灌胃（１０ｇ／ｋｇ）能有效改善神经和免疫功能，而对内分泌系统作用不明显。Experimental Research on the effect of Strenthening the Spleen and Replenishing Qi on Neuroendocrine Immune Network. Chen Xiaohong,Cai Dingfang,Shen Ziyin et al. Huashan hospital,Shanghai Medical University,Shanghai,(200040). To study the regulation of strengthening the spleen and replenishing qi on neuroendocrine immune network,an experimental model of hypothalamus pituitary adrenal thymus(HPAT) axis inhibited by corticosterone(CORT) was established, then we observed the effect of SI JUNZI(SJ) on HPAT axis. Wefound that the content of hypothalamic monoaminic transmitters increased obviously in CORT rtas,the level of ACTH and CORT decreased in plasma,the proliferative reaction of lymphocyte prominently in vitro or in vivo. The content of IL 2 and γ IFN induced by lymphocyte were less than the control After administed 200%SJ, the function of nerve and immune could improve efficiently,while no prominent effect on endocrine. TAOHNG SI WU(TH) had no effect on HPAT axis.

关 键 词：健脾益气 神经内分泌免疫 中医免疫学 

分 类 号：R229[医药卫生—中医基础理论]