Advances in Clinical Pharmacokinetics of Herbal Medicines  

作　　者：Lei Zhang Yuliang Wang Peng Zou Xinzhu Pan Hanming Zhang Wansheng Chen 

机构地区：[1]Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai, Postcode： 200433, China [2]Department of Pharmacy, Faculty of Science, National University of Singapore, Postcode： 119260, Singapore [3]Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, Postcode： 200003, China

出　　处：《Journal of US-China Medical Science》2005年第6期59-72,共14页美中医学（英文版）

基　　金：Supported by the National Natural Science Foundation of China （30371746）

摘　　要：Herbs have been used for treating various ailments since medicine began. The belief that natural products are much safer than synthetic drugs has led to dramatic growth of herbal medicine usage. Like synthetic drugs, herbal preparations also have potential to cause adverse effects and drug interactions. Knowledge of herbal pharmacokinetics is needed to explain and predict various events related to the efficacy and toxicity of herbal preparations. However, Pharmacokinetics and drug interactions of herbal preparation have not been yet systematically studied. Especially, the clinical phannacokinetic studies on herbal preparations are limited to some widely used herbs such as St.John＇s Wort and Gingko biloba. In this review, clinical pharmacokinetics studies that have been conducted for herbal medicine products since 2001 are evaluated. Scientifically controlled clinical studies on various herb-drug interactions are also discussed.

关 键 词：PHARMACOKINETICS HERBAL CLINICAL VOLUNTEER 

分 类 号：R28[医药卫生—中药学]