脱氢表雄酮对大鼠的发育毒性  

The Effects of DHEA on Reproductive Toxicity in Rats

作　　者：林健[1] 何聆[1] 林升清[1] 刘少娟[1] 

机构地区：[1]福建省疾病预防控制中心,福建福州350001

出　　处：《癌变．畸变．突变》2006年第6期479-481,共3页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：背景与目的：探讨脱氢表雄酮（dehydroepiandrosterone，DHEA）的发育毒性。材料与方法：将SD孕鼠随机分为5组，每组16只，分别为阳性对照组（阿司匹林300mg／kg），阴性对照组（蒸馏水）和DHEA10．4、20．8、41．7mg／kg3个剂量组，在受孕第7～16d连续10d给大鼠灌胃DHEA，第20d解剖取出胎鼠，观察DHEA对母体及胎鼠的影响。结果：DHEA剂量在10．4mg／kg时导致孕鼠流产；20．8、41．7mg／kg时孕鼠、胎鼠体重增加减缓，胸骨发育迟缓；41．7mg／kg时，胎鼠内脏畸形增加。3个剂量组胎鼠活胎率均降低。结论：DHEA对孕鼠及胎鼠均有毒性表现。BACKGROUND ＆ AIM： To detect maternal and fetal toxicity of dehydroepiandrosterone（DHEA） MATERIALS AND METHODS： SD pregnant female rats were divided randomly into 5 groups, 16 rats in each group.The rats in positive control group received aspirin 300 mg/ kg and distilled water was given to rats as the negative control group.Three DHEA groups were treated with 10.4,20.8 and 41.7 mg/kg.The rats were given DHEA from 7 d to 16 d of pregnant continuously for 10 days, and were sacrificed on 20th d of pregnancy. Adverse effects on pregnant rats and fetuses were assessed. RESULTS： DHEA at 10.4 mg/kg caused miscarriages in pregnant rats, 20.8 and 41.7 rng/ kg slowed down the weight increase of mother and fetuses, and slowed sternum growth. At 41.7 mg/kg visceral abnormality in fetuses increased.All three concentrations of DHEA decreased the number of living fetuses. CONCLUSION： DHEA had adverse effects in both pregnant rats and fetuses.

关 键 词：脱氢表雄酮 生殖毒性 致畸 流产 大鼠 

分 类 号：R321.6[医药卫生—人体解剖和组织胚胎学]