肝细胞生长因子在纤维肉瘤细胞血行转移中的作用  

Effect of hepatocyte growth factor on transvascular metastasis of sarcoma cells

作　　者：辛华[1] 郑雅娟[2] 韩振国[1] 韩春山[1] 张珂[3] 

机构地区：[1]吉林大学中日联谊医院胸外科,吉林长春130033 [2]吉林大学第二医院眼科,吉林长春130041 [3]吉林省东丰县医院外科

出　　处：《吉林大学学报（医学版）》2006年第6期993-995,共3页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅资助课题(20010526)

摘　　要：目的:评价肝细胞生长因子(HGF)在纤维肉瘤细胞血行转移中的作用。方法:利用体外肿瘤细胞血管内游走及血管外游走模型,定量地评价纤维肉瘤细胞(HT1080)的血行转移情况。结果:HT1080能穿过基底膜和血管内皮细胞游走至血管内,并可通过内皮细胞间缝隙游走至血管外基质;HT1080经HGF预处理后,血管内和血管外游走数量均明显高于对照组(P<0.01)。结论:HGF能够增强纤维肉瘤细胞的运动侵袭能力、加速血行转移。Objective To evaluate the effect of hepatocyte growth factor （HGF） on transvascular metastasis of sarcoma cells. Methods The models of intravascular and extravascular migration of tumor cells in vitro were used to observe transvascular metastasis of sarcoma cells （HT1080）. Results HT1080 migrated through basement membrane into blood vessels, and migrated through a gap between adjacent endothelial cells into extracellular matrix. The greater number of transmigrated HT1080 treated with HGF was observed （P 〈 0.01 ）. Conclusion HGF can stimulate transvascular metastasis of sarcoma cells as a motogen.

关 键 词：肝细胞生长因子 纤维肉瘤 肿瘤转移 

分 类 号：R73-37[医药卫生—肿瘤]