硒碘缺乏对大鼠心肌甲状腺激素代谢和α－磷酸甘油脱氢酶活性的影响  

Effect of combined deficiency of Selenium and Iodine on myocardial thyroid hormone metabolism and α glycerophosphate dehydrogenase activity in rats

作　　者：吴晖云[1] 夏弈明[1] 陈孝曙[1] 田园[1] 顾履珍[1] 

机构地区：[1]北京中国预防医学科学院营养与食品卫生研究所

出　　处：《中国地方病学杂志》1996年第4期215-218,共4页Chinese Jouranl of Endemiology

摘　　要：用缺Ｓｅ缺Ｉ的克山病病区粮为基础，分别添加Ｓｅ或／和Ｉ的饲料喂养４组大鼠。测定了心肌组织Ｓｅ和Ｔ３水平，α－ＧＰＤ、ＩＤＩ、ＧＰｘ活力以及血浆Ｔ４、Ｔ３水平。结果发现，缺Ｉ使大鼠血浆Ｔ４显著下降，而缺Ｓｅ又使适Ｉ大鼠血浆Ｔ４水平增高。所有４组血浆Ｔ３水平波动幅度不大。心肌未能测出ＩＤＩ活性，心肌Ｓｅ含量因饲料加Ｓｅ而增高，但没有影响心肌Ｔ３水平。心肌α－ＧＰＤ活性缺Ｉ组明显低于加Ｉ组，并与血浆Ｔ４水平高度正相关，而与心肌ＧＰｘ活性关系不明显。研究提示，克山病病区粮引起的大鼠心肌低能量代谢特点与缺Ｉ或缺Ｉ引起的ＴＨ代谢异常有明显关系。he effects of combinediodine and selenum deficiency(Se -I -),of single deficiency of these trace elements(Se +I -,Se -I +),and of no deficiency(Se +I +)on the α glycerophosphate dehydrogenase(α GPD)activity were compared in the rat hearts with relation to the thyroid hormone metabolism and GPx activity.No type I 5` deiodinase activity was measured in the four groups,and Se or/and I deficiency has no influence on triiodothyronine level in the rat hearts.There was strong relationship between α GPD activity and plasma thyroxin,but no between α GPDactivity and GPx activity in the hearts.The results indicate that I may be more important than Se in energy metabolism of myocardium,which can be considered as a new clue for the study on the etiology of Keshan disease in which endemic grains are deficient in both Se and I.

关 键 词：硒缺乏 碘缺乏 甲状腺激素 α-GPD 

分 类 号：R591.1[医药卫生—内科学]