缺血性脑卒中患者纤维蛋白原和C-反应蛋白水平与颈动脉粥样硬化的关系  

Relationship of C-reactive protein,fibrinogen and carotid atherosclerosis in ischemic stroke patients.

作　　者：卢锡林[1] 姚晓黎[1] 尚延昌[1] 张成[1] 

机构地区：[1]中山大学附属第一医院神经科,广州510080

出　　处：《中国综合临床》2006年第12期1089-1091,共3页Clinical Medicine of China

基　　金：国家自然科学基金资助项目(30370510);广东省自然科学基金资助项目(30693);广东省科技计划项目(ZKM05501S);广东省博士启动基金资助项目(5300783;04300353)

摘　　要：目的探讨缺血性脑卒中患者颈动脉粥样硬化与纤维蛋白原和高敏C-反应蛋白水平的关系。方法对缺血性脑卒中患者应用颈部多普勒超声检测颈部血管内中膜厚度及斑块形成情况,并同期检测患者血纤维蛋白原和高敏C-反应蛋白浓度。结果125例患者中40例发现有颈动脉粥样硬化病变,其中16例经超声检查诊断为颈动脉粥样硬化斑块,24例诊断为颈动脉内中膜增厚。颈动脉粥样硬化病变的患者平均纤维蛋白原和高敏C-反应蛋白水平显著高于无颈动脉粥样硬化组(P<0.05和P<0.01)。并且随着平均纤维蛋白原水平和高敏C-反应蛋白水平升高颈动脉粥样硬化病变的发生率升高。结论缺血性脑卒中颈动脉粥样硬化和纤维蛋白原、高敏C-反应蛋白水平之间有密切的相关性。Objective To evaluate the relationship of high sensitive C-reactive protein （ hs-CRP） ,fibrinogcn and carotid atherosclerosis in ischemic stroke patients. Methods The ischemic stroke patients underwent ecocolordoppler examination to detect the intima-media thickncss （IMT） and the plaque formation of the common carotid arteries. A blood sample was drawn to evaluate the concentration of hs-CRP and fibrinogen, Results 125 ischemic stroke patients were included. There were 40 patients with carotid atherosclerosis disorders, 16 of whom were diagonosed with carotid atherosclerosis plaque and 24 with increased IMT. The average levels of fibrinogen and hs-CRP were significantly higher in patients with carotid atherosclerosis disorders than those without carotid atherosclerosis disorders （ P 〈 0.05 and P 〈 0.01 ）. The increase in thc incidence of carotid atherosclerosis was associated with the increase in the levels of fibrinogen and hs-CRP. Conclusion The high plasma levcls of hs-CRP and fibrinogen are strongly associated with carotid atherosclerosis in patients with ischemic stroke inpaticnts.

关 键 词：缺血性脑卒中 颈动脉粥样硬化 纤维蛋白原 C-反应蛋白 

分 类 号：R743[医药卫生—神经病学与精神病学]