关于卵巢癌遗传学研究技术新进展  

The Progress of Study Technique in Ovarian Cancer Genetics

作　　者：黎静[1] 钟梅[1] 

机构地区：[1]第一军医大学附属医院南方医院妇产科,广州510515

出　　处：《医学综述》2006年第23期1440-1442,共3页Medical Recapitulate

摘　　要：人类肿瘤的发生和发展常与染色体异常有关,这种非随机性的异常主要包括了染色体的丢失、获得、扩增和重排等。随着遗传学研究技术不断地深入,人们在荧光原位杂交技术(FISH)上建立了比较基因组杂交技术(CGH)、微阵列比较基因组杂交技术(arrayCGH),并广泛应用于细胞遗传学、肿瘤生物学上,本文就卵巢癌遗传学技术的最新进展作一综述。The genesis and development of human cancer is often associated with chromosomal abnornudities, this nonrandomness abnonnity mainly includes chromosomal loss, obtain, amplification, rearrangement and so on. with the development of research technique in genetics, the technique of comparative genomic hybridization （CGH） and array based comparative genomic hybridization （array CGH） which are based on fluorescence in situ hybridization（FISH） ,has been applied widely in cytogenetics and oncobiology. This article reviews the progress of study technique in ovarian cancer genetics.

关 键 词：卵巢癌 荧光原位杂变技术 比较基因组杂交技术 微阵列 

分 类 号：R737.31[医药卫生—肿瘤]