114对反复流产夫妇的染色体分析  

Chromosome analysis of 114 couples with recurrent spontaneous abortion

作　　者：周波[1] 唐艳平[2] 杨真荣[2] 陈燕[2] 

机构地区：[1]温州医学院生命科学院生物系,浙江温州325035 [2]华中科技大学同济医学院生物系

出　　处：《中国妇幼保健》2007年第1期126-128,共3页Maternal and Child Health Care of China

摘　　要：目的:分析反复流产夫妇的异常核型发生率、形成原因及其染色体分析的临床价值。方法:对114对反复流产夫妇行外周血染色体分析。结果:检出异常染色体核型13例,占受检夫妇人数的5·7%,异常核型中,平衡易位最多,占异常总数的76·92%,其中相互易位10例,罗伯逊易位3例;其次为倒位,为6号、9号以及Y染色体的臂间倒位。结论:对于不明原因的反复流产夫妇,染色体分析必须作为常规的检测方法。Objective： To analyze the incidence and reasons of abnormal karyotypes and clinical value of chromosome analysis in recurrent spontaneous abortion （RSA） . Methods： Chromosome analysis was performed on 114 couples with RSA. Results： 13 cases of abnormal karyotypes were detected （5.7%） . Balanced translocations had the most abnormalities （76. 92% ）, including 10 balanced reciprocal translocations and 3 balanced Robertsonian translocations. The other types of abnormal karyotpyes were balanced pericentric inversions, affected chromosome 6, 9 and Y. Conclusion： Chromosomal analysis should be carried out routinely in every couple with unexplained failure of reproduction.

关 键 词：反复流产 染色体异常 倒位 

分 类 号：R715[医药卫生—妇产科学]