普伐他汀对急性脑梗死患者血清中氧化修饰低密度脂蛋白、转化生长因子β1、血管细胞间黏附分子-1和血脂水平的影响  

Effects of Pravastatin on serum ox-LDL,TGF-β1,VCAM-1 and lipid levels in patients with acute cerebral infarction

作　　者：郭正良[1] 傅毅[1] 辛晓瑜[1] 曾丽莉[1] 沈介明[1] 刘建荣[1] 陈生弟[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院神经科,200025

出　　处：《临床神经病学杂志》2007年第1期53-55,共3页Journal of Clinical Neurology

基　　金：上海市科学技术委员会重大科研项目基金(03DZ19702)

摘　　要：目的探讨普伐他汀对急性脑梗死(ACI)患者血清中氧化修饰低密度脂蛋白(ox-LDL)、转化生长因子β1(TGF-β1)、血管细胞间黏附分子-1(VCAM-1)和血脂水平的影响。方法将114例ACI患者随机分为普伐他汀联合阿司匹林治疗组(56例)和阿司匹林治疗组(58例)。分别在发病72h内和治疗后3个月检测血清中ox-LDL、TGF-β1、VCAM-1和血脂浓度,并进行比较,同时取门诊体检者(50名)设为健康对照组。结果普伐他汀联合阿司匹林治疗组和阿司匹林治疗组的患者发病72h内血清ox-LDL、VCAM-1、血胆固醇和LDL的浓度高于健康对照组(均P<0.05),TGF-β1的浓度低于健康对照组(P<0.05)。与治疗前及阿司匹林组相比,普伐他汀联合阿司匹林治疗组在治疗第3个月时血清ox-LDL、VCAM-1、血胆固醇、血LDL浓度明显下降,血清TGF-β1明显升高(均P<0.05)。结论普伐他汀有利于降低血清ox-LDL的浓度,调节免疫功能,抑制炎症反应,从而进一步稳定动脉粥样斑块,可作为治疗ACI患者的联合药物。Objective To investigate the effects of Pravastatin on serum oxidative modified LDL （ox-LDL）, tumor growth factor β1 （TGF-β1）, vascular cell adhesion molecule-1 （VCAM-1） and lipid levels in patients with acute cerebral infarction（ACI）. Methods 114 cases with ACI were randomly divided into two therapy groups ： （ 1 ） 56 cases were given Pravastatin combined with Aspirin; （2） 58 cases were treated with Aspirin only. The serum levels of ox-LDL, TGF-β1, VCAM-1 and lipid were detected 72 h after the onset of the disease and 3 months following the treatment. Meanwhile, the same were detected in the control group （50 healthy people）. Results Within 72 h, the serum levels of ox-LDL, VCAM-1, cholesterol and LDL were higher in patients with ACI than those in control group（ all P 〈0. 05）. The serum level of TGF-β1 was lower in patients with ACI than that in control group （P〈0. 05）. Compared with before treatment and Aspirin therapy group, the serum levels of ox-LDL, VCAM-1, cholesterol and LDL were obviously decreased and the serum TGF-β1 increased in Pravastatin combined with Aspirin therapy group 3 months after the treatment （ all P 〈 0. 05）. Conclusions Pravastatin may benefit lowering the serum level of ox-LDL, modulating immunological function and restraining inflammation so that it can further stabilize artery atheromatous plaque. Therefore, Pravastatin combined with Aspirin can be a good approach to treating ACI.

关 键 词：普伐他汀 脑梗死 氧化修饰低密度脂蛋白 转化生长因子Β-1 血管细胞间黏附分子-1 

分 类 号：R743.3[医药卫生—神经病学与精神病学]